Role and regulation of specialized metabolites in a permanent plant-bacterium symbiosis

不同的植物物种已经进化出与它们叶子中的细菌永久或专有的联系。共生菌合成特定代谢物几乎是这些共生体的普遍特征。然而，我们对这些代谢物的功能作用知之甚少，也不知道支配这些联系的空间和时间信号事件。Resids的目标是利用独特的易驯化的叶片共生来测试细菌新陈代谢有助于植物抵御食草动物和竞争对手的假设。这将通过分离和表征共生伙伴之间的化学和分子信号来实现。法国和德国小组在植物共生的微生物学和天然产物化学方面的互补专业知识为解决植物如何控制叶表面微生物的传播、定植和功能这一令人兴奋的问题提供了理想的框架。

Various plant species have evolved permanent or obligate associations with bacteria in their leaves. The synthesis of specialized metabolites by the symbiotic bacteria is a near universal feature of these symbioses. Yet, we know little of the functional roles of these metabolites, or the spatial and temporal signaling events that govern these associations. The objective of RESIDE is to leverage a uniquely tractable leaf symbiosis to test the hypothesis that bacterial metabolism contributes to plant defense against herbivores and competitors. This will be achieved via isolation and characterization of the chemical and molecular signals between the symbiotic partners. The complementary expertise of the French and German groups in the microbiology and natural product chemistry of plant symbioses provide the ideal frame to address the exciting question of how plants control the transmission, colonization and function of microbes at the leaf surface.