Comprehensive study on research and development of circulatory assist systems for bettering therapeutic outcome of severe heart failure pediatric patients

我们开发了几种类型的下一代儿科循环支持系统。心肺支持系统具有长期耐用性和优良的上级抗血栓性能，可提供安全的长期心肺支持，有望成为高死亡率感染性疾病可能大流行的最终治疗选择。我们还进行了三种不同类型的人工心脏的研发：1）NCVC型气动旁路小儿心室辅助装置，2）婴儿植入式轴流式心室辅助装置，3）超紧凑型植入式轴流式小儿心室辅助装置（带流体动力轴承）。所有系统都取得了显著进展，并分别进入：1）1年内的药物应用，2）产品设计阶段，3）预临床试验阶段。我们的研发活动将继续并加速，旨在尽早临床应用。

We developed several types of next-generation pediatric circulatory support systems. The cardiopulmonary support system with long-term durability and superior antithrombotic property can provide safe long-term cardiopulmonary support, and is expected as ultimate therapeutic option for the possible pandemic of high mortality infectious diseases. We also proceeded research and development of three different types of artificial hearts: 1) NCVC type pneumatic paracorporeal pediatric ventricular assist device, 2) implantable axial flow ventricular assist device for infants, and 3) ultra-compact implantable axial flow pediatric ventricular assist device with hydrodynamic bearings. All systems have significantly progressed and came to: 1) pharmaceutical application within 1 year, 2) product design phase, and 3) preclicnical test phase, respectively. Our research and development activity will be continued and accelerated, aiming at earliest clinical application.