Structure and function of novel macrophage proteins using high throughput crystallography

我们将结合微阵列分析和高通量晶体学的尖端技术，以一种创新的方法来研究重要的和未表征的巨噬细胞蛋白的结构和功能。我们针对新型巨噬细胞蛋白的策略将最大限度地提高结构测定的成功率，同时将我们的努力集中在巨噬细胞生物学中重要的蛋白质上。新蛋白的结构将在分子水平上支持功能分析，并可能代表抑制剂设计的基础，如果蛋白质最终被证明是治疗靶点。

We will combine the cutting edge technologies of microarray analysis and high throughput crystallography in an innovative approach to study the structure and function of important and uncharacterised macrophage proteins. Our strategy for targeting novel macrophage proteins will maximise the success rate of structure determination, while at the same time focusing our efforts on proteins that are important in macrophage biology. Structures of the novel proteins will underpin functional analysis at a molecular level and could represent a basis for inhibitor design should the proteins ultimately be shown to be therapeutic targets.