How does Clostridium perfringens carry multiple closely related plasmids?

该项目旨在确定细菌如何能够在同一细胞中复制和维持非常密切相关的染色体外元素或质粒的多个拷贝。这些质粒很重要，因为它们编码毒素基因和抗生素抗性基因。该项目提出检验两个基本假设，假设来解释这种新现象。该项目的预期成果是推进有关在食品生产动物中引起疾病的细菌如何保持使其引起这些疾病的遗传元素的基础知识。这将有助于我们了解这些具有重要经济意义的动物病原体的流行病学，并可能支持开发新的预防或治疗方法。

The project aims to determine how bacteria are able to replicate and maintain multiple copies of very closely related extrachromosomal elements or plasmids in the same cell. These plasmids are important as they encode toxin genes and antibiotic resistance genes. The project proposes to examine two fundamental hypotheses that are postulated to explain this novel phenomenon. The anticipated outcome of the project is the advancement of fundamental knowledge of how bacteria that cause disease in food-production animals can maintain the genetic elements that enable them to cause these diseases. This would contribute to our understanding of the epidemiology of these economically significant animal pathogens and may support the development of new methods of prevention or treatment.