Luminescent inorganic-organic hybrid particles for a combinatorial in-situ fluorescence detection of temperature and pH value (FL-Detect)

在杂化材料领域，该项目针对表现出发光的无机-有机杂化粒子，并显示这种性质随温度和pH值的变化。这应该允许对温度及其变化进行光学检测，以及检测系统的pH值和相应的变化以及单项和同时分析。为了实现这一目标，杂化材料的选择是基于两个研究小组的专业知识：费尔德曼组的无机-有机纳米粒子(AOH-NP)和Müler-Buschbaum组的金属-有机骨架(MOF)和配位聚合物(CPS)。选定的化合物将在各自的基团中合成，研究所描述的检测选项，并相应地进行表征。单一化合物的发光可以在特定的温度和pH值范围内发生变化。基于荧光的检测来自不同的过程，诸如热猝灭或例如质子化/去质子化，并且可能导致强度的显著改变(关闭/开启)或发光的色度的显著改变，从而能够进行“原位”检测。此外，来自两个领域的合适候选者将被组合成更复杂的杂化材料，以便协同利用两种或两种以上的单一效应。这将导致可检测到大范围的温度和PH值。总而言之，来自这两类化合物和材料的适当组合将被用来获得荧光温度计和发光pH纸。

In the field of hybrid materials, the project aims at inorganic-organic hybrid particles that exhibit luminescence as well as show a change of this property based on temperature and pH-value. This is supposed to allow for an optical detection of temperature and its alteration as well as for a detection of the pH-values of a system and a respective variation as singular as well as simultaneous analyses. In order to achieve this goal, hybrid materials have been selected according to the expertise of the two research groups that exhibit broad luminescence properties: inorganic-organic nanoparticle (AOH-NP) in the group Feldmann and metal-organic frameworks (MOFs) and coordination polymers (CPs) in the group Müller-Buschbaum. Selected compounds will be synthesized in the respective groups, investigated for the described detection options and characterized accordingly. Single compounds can undergo a change in their luminescence for a specific region of temperature and pH value. Fluorescence based detection results from distinct processes such as thermal quenching or e.g., protonation/deprotonation, and can either result in a significant alteration of intensity (“turn-off/turn-on”) or of the chromaticity of the luminescence enabling an “in-situ” detection. Furthermore, suitable candidates from both fields will be combined to even more complex hybrid materials in order to synergistically utilize two or more single effects. This shall lead to a broad range of temperature and pH being detectable. Altogether, the suitable combination of compounds and materials from both groups will be used to achieve a fluorescence thermometer as well as luminescent pH paper.