Pulmonary Aspergillus infection progression determined by alveolar macrophages as initial responders (A06)

我们将研究肺泡巨噬细胞（AMs）在遇到致病性真菌烟曲霉（Aspergillus fumigatus）时的最早决策点，并询问先前暴露于其他病原体的影响，这些病原体似乎决定性地改变了肺免疫监测。A06旨在通过AM-肺泡上皮细胞的密切相互作用或通过募集其他免疫细胞（如中性粒细胞、单核细胞和树突状细胞），查明导致烟曲霉在肺泡空间环境中有效控制的细胞和分子决定因素。

A06 we will investigate the earliest decision points in alveolar macrophages (AMs) upon encounter with the pathogenic fungus Aspergillus fumigatus and interrogate the impact of previous exposures to other pathogens that appear to decisively alter lung immune surveillance. A06 aims to pinpoint cellular and molecular determinants resulting in an effective control of A. fumigatus in the alveolar space environment either by close AM- alveolar epithelial cells interactions or through recruitment of other immune cells such as neutrophilic granulocytes, monocytes and dendritic cells.