Mechanisms of action and expression of bioactive compounds produced by the surface associated marine bacterium Pseudoalteromonas tunicata

海洋表面相关细菌被膜假交替单胞菌（Pseudoalteromonas tunicata）产生许多生物活性代谢物，其抑制常见污损生物如细菌、真菌、藻类和无脊椎动物幼虫的定殖和生长。抗细菌和抗真菌化合物代表了对医学和农业上重要的细菌和真菌具有显著活性的新型代谢物。该项目旨在探索这些化合物的身份，作用模式和表达调控。这项研究提案涉及几个重要的生物学概念，并将导致新的环境友好型抗菌和抗菌技术的发展。

The marine surface-associated bacterium Pseudoalteromonas tunicata produces a number of bioactive metabolites that inhibit the colonisation and growth of common fouling organisms such as bacteria, fungi, algae and invertebrate larvae. The antibacterial and antifungal compounds represent novel metabolites active against a remarkable range of both medically and agriculturally important bacteria and fungi. This project aims to explore the identity, mode of action and regulation of expression of these compounds. This research proposal addresses several significant biological concepts and will lead to the development of novel environmentally friendly antifouling and antimicrobial technologies.