Multi-Dimensional Interactions in Ensembled Molecular System

阐明系综分子系统中的多维相互作用对于从分子水平上理解生物过程、先进材料的功能设计以及药物和农用化学品的分子设计具有重要意义。在本研究项目中，我们与美国华盛顿大学的阿克曼教授的研究小组进行了验证，以促进我所新近引进的三维结构分析系统的广泛应用。我们为我所的研究人员举办了两次研讨会，内容涉及高场核磁共振(MR)谱和高分辨率质谱学的理论和实践方面。我们研究所的六位教授访问了华盛顿大学，以证实以下具体研究项目：(1)基于手性分子的多维相互作用开发合理设计的不对称催化剂，(2)定量处理有机材料的固相功能与其核磁共振谱之间的关系，(3)基于对多维相互作用的分子水平的理解进行生物活性分子的分子设计。

The elucidation of multi-dimensional interactions in ensembled molecular system is of significant importance for the molecular-level understanding of biological processes, for the functional design of advanced materials, and for the molecular design of pharmaceuticals and agrochemicals, In the present research project, we corroborated with the research group of Prof. Ackerman of Washington university (USA) to promote die extensive utilization of three-dimensional structural-analysis system recently introduced to our institute.Two seminars were held for the researchers of our institute on the theoretical and practical aspects of a high-field nuclear magnetic resonance (MR) spectrometry as well as high-resolution mass spectrometry. Six professors of our institute visited Washington university to corroborate on the following specific research projects : (1) development of a rationally designed asymmetric catalysts based on the multi-dimensional interactions of chiral molecules, (2) quantitative treatment of the relation between the solid-phase function of organic materials and their NMR spectra, and (3) molecular design of bioactive molecules based on die molecular-level understanding of the multi-dimensional interactions.