Research of Gene therapy for patients with head and neck carcinomas using CyclinD1

对头颈部鳞状细胞癌患者的生物学恶性程度进行了研究。为探讨头颈部鳞状细胞癌中细胞周期蛋白D_1基因扩增和蛋白过度表达对患者预后的影响。头颈部鳞状细胞癌组织中Cyclin D1基因扩增和蛋白过度表达可作为判断头颈部鳞状细胞癌生物学恶性程度和预后的指标。这些结果提示使用细胞周期蛋白D_1基因治疗头颈癌是可行的。

The grading of biological malignancy was studied in patients with head and neck squamous cell carcinomas. The studies concerning the amplification of the cyclinD1 gene and overexpression of cyclinD1 protein in head and neck squamous cell carcinomas were studied to evaluate the prognostic significance of patients. The amplification of cyclinD1 gene and overexpression of cyclinD1 protein in head and neck squamous cell carcinomas were considered to be useful for assessment of biological malignancy and prognosis in head and neck squamous cell carcinomas. These results suggest the approach for genetherapy using cyclinD1 for patients with head and neck carcinomas.