Etiopathogenesis of Immunological Diseases: Cell Sociological aspect of tissue-destructive mechanisms on them

顽固性炎症性疾病几乎占据了所有的“胶原病”，似乎在某种程度上受到免疫紊乱。这些疾病的发病机制可能非常复杂，因为疾病的主要特征完全被次级或三级宿主反应所掩盖。免疫学的最新进展使得有可能解释这些疾病的原发性疾病或传入臂的机制，但在肉芽肿中发现的组织破坏机制中的传出臂仍然不清楚。我们试图澄清后者的基础上“细胞社会学之间的细胞相互作用的攻击者，受害者和质问者”如下。应用免疫组化方法对肾小球肾炎、血管炎和肾小球球瘤等免疫性疾病的基本病理特征进行了分析。阐明了疾病发展和进展的一些宿主原因，并以新途径和新方法研究了其中四种：（1）免疫复合物：IgG的分子操作以分析其效应器功能，（2）逆转录病毒：其在免疫细胞溶解中作用的免疫病理学和病毒学分析，（3）巨噬细胞：其功能异常在肉芽肿性病变发展中的重要作用，以及调节细胞因子对巨噬细胞的作用，以及（4）T细胞产物：作为抑制剂的重要性，但有时是顽固性炎症病变的加速剂。

Intractable inflammatory diseases occupying almost all of "Collagen Diseases" seem to be somehow under immunological disturbance. The etiopathogenesis of such diseases may be much complicated as the primary feature of disease is completely hidden by secondary or tertiary host reactions. Recent advances in immunology make it possible to explain the mechanisms on primary disorders or afferent arms of these diseases, but the efferent arms in tissue-destructive mechanisms as found in granulomas are still obscure. We tired to clarify the latter on the basis of "cell sociology among cell to cell interactions of assailants, sufferers and hecklers" as follows.A. The basic pathological feature in immunological diseases; glomerulonephritis, angitis and glanulomas were analyzed in immunohistochemical studies using monoclonal antibodies against various cell surface antigens.B. Some host causes for development and progression of the diseases were eluted and four of them were studied in new approachs and new methods;(1) immune complexes:molecular manipulations of IgG to analyze their effector functions,(2) retroviruses :immunopathological and virological analysis of their roles in immunocytolysis,(3) macrophages :significant roles of their functional abnormalities in the development of granulomatous lesions, and roles of regulatory cytokines to macrophages, and(4) T cell products :significance as inhibitors but sometimes accelerators against intractable inflammatory lesions.