Integrative studies on the thermosensitivity of living body and the onset of thermoregulatory responses.

1.温度敏感神经元的研究。(1)视前温热可促进视上神经分泌细胞和脑室旁神经分泌细胞的活动。(2)大鼠阴囊加温不仅引起体温调节反应，还引起脑电去同步化等非特异性反应。(3)在较高的脑温下，下丘脑后部可见温敏神经元呈开关反应。(4)&lt；CO_2&gt；在体内对温度敏感神经元有刺激作用，而在体外有抑制作用。体温调节效应器的研究。(1)视前区产生的温度信号被传递到控制棕色脂肪组织产热的下丘脑腹内侧核。(2)观察不同实验条件下麻醉大鼠的唾液分泌情况。中枢和外周温度信号被整合以产生流口水。视前升温导致唾液分泌和身体伸展，而下丘脑后部升温引起梳理。(3)在不同的内外热应力条件下，观察到加载棒压力对颅内的自激作用。(4)跑步机运动大鼠的直肠温度随运动强度的增加而增加。

1. Studies on thermosensitive neurons. (1) Activities of supraoptic and para-ventricular neurosecretory cells were facilitated by preoptic warming. (2) Scrotal warming in rats produced not only thermoregulatory responses but also non-specific responses such as EEG desynchronization. (3) Warm-sensitive neurons showing on-off type response at higher brain temperature were found in the posterior hypothalamus. (4) <CO_2> stimulated thermosensitive neurons in vivo, but depressed in vitro.2. Studies on thermoregulatory effectors. (1) Temperature signals generated in the preoptic area were transmitted to the hypothalamic ventromedial nucleus, which controlled brown adipose tissue thermogenesis. (2) Saliva secretion in anesthetized rats were observed at various experimental conditions. Central and peripheral temperature signals were integrated to produce salivation. Preoptic warming produced saliva secretion and body extension, while warming of the posterior hypothalamus caused grooming. (3) Intracranial self-stimulation with loaded bar press was observed at various internal and external thermal stresses. (4) Rectal temperature of rats running on a treadmill increased in proportion to the exercise intensity.