Sex Difference of Free Erythrocyte Protoporphyrin (FEP) in Humans and Rats

铅暴露和铁缺陷动物的几个生物参数，如FEP，<delta>-氨基维ulinic acid脱氢酶（ALA-D），血清铁（FeS）， HT， Hb等，对98名妇女和59名男子进行了测量（共51 &lt;-!+&gt; 11岁）生活在农村地区，妇女展示了比男子更高的FEP水平; 63.0 &lt;-!+&gt; 19.4在妇女和54.6 &lt;!+&gt; 21.2 g<mu>/dl·pcv in men.女性PB-B级表现出比男性更低的趋势。Ht， Hb和FES也比男人更低。ALA-D活动在两种性别之间没有区别;这些生物参数之间的相关性是计算的，而Pb-B和这些参数之间没有明显的相关性。Ht、Hb和FEP之间有一些微小的相关关系。在老鼠被注射的铅（0.5毫克Pb/公斤·BWX 6）和控制， FEP水平低于男性，同样的模式出现在<delta>初级氨基维酸（ALA-U）中。在高铅剂量组（5毫克Pb/千克BWX 6）、尿中双酚啉（CP-U）的女性低于男性，在其他有笼状雄性大鼠、雌二醇（50， 250<mu>克/千克·BWX 22）的研究中被注射到有或没有铅（5毫克Pb/千克BWX 6）的老鼠中。在FEP、ALA-U和CP-U中，没有明显的增加导致雌激素在两种大鼠中都有或没有铅，当雌激素在HT和身体重量中减少时，雌激素显示了雌激素的减少。这些结果建议说，FEP在人类女性中的增加并没有因性激素而导致，并且主要是由于铁缺乏性贫血引起的趋势而导致的，由于血液损失而导致的趋势。（i. e. menses、pregnancy、delivery等）和饮食习惯的差异（食品质量和数量等）。

Several biological parameters of lead exposure and iron deficiency anemia, such as FEP, <delta> -aminolevulinic acid dehydratase (ALA-D), Serum iron (FeS), Ht, Hb etc, were measured for 98 women and 59 men (both 51 <-!+> 11 years old) lived in rural districts.Women showed a higher FEP level than men; 63.0 <-!+> 19.4 in women and 54.6 <-!+> 21.2 <mu> g/dl・pcv in men. Women Pb-B level showed a lower tendency than in men. Ht, Hb and FeS were also lower in women than in men. There was no difference in ALA-D activity between both sexes.Correlations between these biological parameters were calculated, and no significant correlations were observed between Pb-B and these parameters. There were a little correlations between Ht, Hb and FEP for FeS.In rats injected lead (0.5 mg Pb/kg・BWX6) and the control, FEP level was lower in female than in male, and the same pattern was observed in urinary <delta> -aminolevulinic acid (ALA-U). In high lead dose group (5 mg Pb/kg.BWX6), urinary coproporphyrin (CP-U) was lower in female than in male.In another study with castrated male rats, estradiol (50, 250 <mu> g/kg・BWX22) was injected into the rats with or without lead (5 mg Pb/kg.BWX6). No significant increase due to estradiol was observed in FEP, ALA-U and CP-U in both rats with or without lead, while a decrease in Ht and body weight by estradiol was shown.These results suggest that the increase of FEP in human females is not caused by sex hormone, and mainly caused by tendency of iron deficiency anemia induced by blood loss (i.e. menses, pregnancy, delivery etc) and the differences of dietary habits (quality and quantity of food etc).