Experimental and Clinical Study for Atrial Natriuretic Hormone and Hemodynamics on Surgical Stress

为了澄清大气自然多肽（ ANP ）对外科压力的病理学作用和药理学效应，我们研究了由北肾上腺素诱导的等离子体ANP水平和ANP对寡肽模型的效应。（ 1 ）等离子体ANP水平跟随外科压力。血液样本是从生理性癌症患者手术前后采集的。Moreover，Swan-Ganzcatheter对血动力学的各种参数进行了测量。等离子体ANP水平在操作前低于40 pg/ml。Tese在运行后1、2、3、4天后运行后1、2、3、4天内进行了显著提高，但没有测试到6218（MSD）， 59 24 5013、5115 pg/ml。凡士林和奥尔多斯泰隆在1、2天后表现出他们的高峰期，尊重地。等离子体ANP水平不与CVP和PWP有关。（ 2 ）ANP对外科压力的药理学效应，我们调查了ANP对寡藻和周边循环系统崩溃的效应，并通过高钙胺的超结构诱导。在北肾上腺素的恒定灌注（ 4 /kg·min ）为20分钟后，-hANP（ 1 /kg·min ）或多巴胺（ 3 /kg·min ）为20分钟的恒定灌注管理，北肾上腺素的胰岛素输出被管理超过4次。在另一边，这些影响并没有被多巴胺所观察到。

To clarify the pathophysiological role and phamacological effect of atrial natriuretic polypeptide ( ANP ) on surgical stress, we investigated the plasma ANP levels following the operation and the ANP's effect on oliguric models induced by norepinephrine.( 1 ) Plasama ANP levels following surgical stress. Blood samples were obtained from esophageal cancer patients before and after operations. Moreover, various parameters of hemodynamics were measured by Swan-Ganzcatheter. The plasma ANP levels were under 40 pg/ml before operations. Tese were elevated significantly by student's t test up to 62 18(M SD), 59 24 50 13, 51 15 pg/ml on 1, 2, 3, 4 postoperatinve day, respectively. Vasopressine and aldostelon showed their peaks on 1, 2 postoperative day, respectively. The plasma ANP levels were not coresponded to CVP and PWP.( 2 ) Phamocological effect of ANP on surgical stress We investigated the effect of ANP on a oliguria and peripheral circulatory collapse induced by a hypersecretion of cathecolamine. After the constant infusion of norepinephirine ( 4 /kg・min ) for 20 min, -hANP ( 1 /kg・min ) or Dopamin ( 3 /kg・min ) was administrated by constant infusion for 20 min. Urine outputs decreased by the administration of norepinephrine were increased more than 4 times by ANP. On the other hand, these effect was not observed by dopamin.