Clinical and experimental study of the nuclear DNA content in the colo-rectal cancer.

采用显微分光光度法检测细胞核DNA含量，以客观评价结直肠癌个体的恶性程度，特别是预后。DNA含量与肿瘤的部位、直径、侵犯深度、组织学类型和分期无关，但与血管侵犯、淋巴结转移和肝转移有关。有静脉侵犯或肝转移的病例DNA含量明显高于无上述发现的病例。2C区出现模式值或平均值的病例的五年生存率高于3C区或以上的病例。核DNA含量似乎与预后及各种组织病理学特征有关。目前，大鼠实验性结直肠癌的发生发展与核DNA含量的相关性正在观察中。

The nuclear DNA content was measured by microspectrophotometry in order to objectively evaluate malignancy of individual colo-rectal cancers,with particular concern to prognosis. Although the DNA content did not correlate to the location, diameter,invasion depth, histological type and staging,it was seen to be related to vessel invasion,lymphnode metastasis and liver metastasis. The DNA content in cases with venous invasion or liver metastasis was significantly greater than in those without the above-described findings.Those cases in which modal value or mean value was presented in the 2C region showed higher five-year survial rates than did those presented in the 3C region or over.The nuclear DNA content seemed to be correlated to the prognosis as well as various histopathological features.The correlation between the developping of the experimental colo-rectal cancer in the rat and nuclear DNA content was observing,now.