Release of vasoactive intestinal peptide in canine septic shock

血管活性肠肽（VIP）是一种有效的血管扩张剂和降压肽，在犬感染性休克的靶器官肠道中存在高浓度。我们已经验证了VIP可能在麻醉犬的脓毒性休克期间释放到循环中，并可能影响这种疾病的发病机制和结果。结果表明：(1)各组大鼠血浆VIP水平均显著升高，(2)MPSS/TOB组大鼠血浆VIP浓度升高不明显；(3) VIP浓度在初始升高后逐渐下降与生存率提高相关；(4) MPSS/TOB治疗大肠杆菌致休克比单用TOB治疗更能提高患者的生存率。我们得出结论，在大肠杆菌诱导的麻醉犬休克期间，循环VIP水平升高，VIP释放可能在脓毒性休克的生理改变中发挥介质-调节作用。

Vasoactive intestinal peptide (VIP), a potent vasodilator and hypotensive peptide, is present in high concentrations in the gut, a target organ in canine septic shock. We have tested the hypothesis VIP may be released into the circulation during septic shock in anesthetized dogs and may influence the pathogenesis and outcome of this disorder.The results suggest that (1) Plasma VIP levels increased markedly in all animals receiving E.coli, (2) the increase in plasma VIP concentrations was less pronounced in the group receiving MPSS/TOB infusions;(3) progressive decline in VIP concentration after the initial rise was associated with enhanced survial; and (4) MPSS/TOB therapy of shock induced by E.coli was more effective than TOB alone in improving survival.We conclude that circulating VIP levels increase during shock induced by E.coli in anesthetized dogs and that the VIP release may play a mediator-modulator role in the altered Physiology of septic shock.