Biotechnology applications in the veterinary pharmaceutical industry: Pharmacological manipulation of ovarian function in domestic animals

本研究的目的是开发一种人道、简单、安全、有效的雌性家畜绝育方法，无需手术干预。这种新颖的实验策略是针对雌性哺乳动物卵巢中休眠卵的供应。每只雌性哺乳动物出生时，卵巢皮层的卵子供应都是有限的。这些细胞不能分裂，所以当储存耗尽时，繁殖就停止了。我们的策略是开发药物试剂来摧毁这些休眠的卵子，从而使这些动物瞬间且不可逆转地不育。

The purpose of this research is to develop a humane, simple, safe, effective means of sterilizing female domestic animals without the need for surgical intervention. This novel experimental strategy is to target the supply of dormant eggs in the ovaries of female mammals. Every female mammal is born with a finite supply of eggs in the ovarian cortex. These cells cannot divide and so when this store is exhausted, reproduction ceases. Our strategy is to develop pharmaceutical reagents that will destroy this dormant egg population, thereby rendering the animals instantaneously and irreversibly infertile.