Waisman Center Intellectual and Developmental Disabilities Research Center
魏斯曼中心智力与发育障碍研究中心
基本信息
- 批准号:10239776
- 负责人:
- 金额:$ 122.68万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-15 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAgricultureAnimalsAttention deficit hyperactivity disorderAwardBehavioralBioinformaticsBiologicalBiological Response Modifier TherapyBiological SciencesBiometryBrain imagingChildClinicalClinical ResearchClinical TrialsClinical assessmentsCognitive TherapyCommunitiesConsultationsDevelopmentDiagnostic ServicesEcologyEducational workshopElectroencephalographyEngineeringEnvironmentExposure toFacultyFamilyFellowshipFosteringFundingGenerationsGenetic EngineeringGenomicsHealth Services ResearchHomeHumanHuman Cell LineImaging DeviceIndividualInstitutesIntellectual and Developmental Disabilities Research CentersIntellectual functioning disabilityInterventionInvestigationJointsK-Series Research Career ProgramsKnowledgeLaboratoriesLanguage DisordersLettersLiquid substanceLocationMachine LearningMagnetic Resonance ImagingMentorsMethodsMissionModelingMolecularMouse StrainsNational Institute of Child Health and Human DevelopmentNeurosciencesNursery SchoolsParticipantPathologyPositron-Emission TomographyPreventionPrivatizationProductionProductivityProgram DevelopmentPublic HealthQuality of lifeRattusRequest for ApplicationsResearchResearch PersonnelResearch Project GrantsResourcesRodentScanningSchoolsScienceScientific Advances and AccomplishmentsScientistSeasonsSeriesServicesSocial WorkSumSymptomsSystemTeacher Professional DevelopmentTechniquesTimeTrainingTraining ProgramsTranslational ResearchUnited States National Institutes of HealthUniversitiesVeterinary MedicineWisconsinautistic childrenbasebehavioral phenotypingbiobehaviorcollaborative approachcollegecommunity cliniccost effectivedesignexperiencehuman pluripotent stem cellinnovationinstrumentationinterdisciplinary approachinterdisciplinary collaborationleadership developmentmedical schoolsmeetingsmethod developmentmicroPETmutantnervous system disorderneurobehavioralneurodevelopmentneuroimagingnext generationnonhuman primatepost-doctoral trainingpre-doctoralprogramsrecruitscience educationspecial interest groupstem cellstraining opportunitytranslational research programtreatment servicesundergraduate student
项目摘要
We seek continued support of the Waisman Center Intellectual and Developmental Disabilities Research Center,
a comprehensive interdisciplinary program focused on IDD spanning the biological, behavioral, and biomedical
sciences. The Waisman IDDRC brings together 60 PIs from 24 academic departments from the UW-Madison’s
Schools of Medicine and Public Health, Veterinary Medicine, Agriculture and Life Sciences, Letters and Science,
Education, Engineering, Social Work, and Human Ecology. This application requests support for an
Administrative Core (Core A), providing scientific leadership, program and faculty development, facilitation of
interdisciplinary collaboration, oversight of training programs, biostatistical and bioinformatics expertise; and
dissemination of knowledges and best practices; and three innovative scientific core services: Clinical
Translational (Core B), providing services, resources, and training in the recruitment of human participants,
clinical research coordination/navigation, clinical assessment, behavioral methods development, and production
of clinical grade biotherapeutics for use in clinical trials; Brain Imaging (Core C), providing access to state-of-
the-art neuroimaging instrumentation for both human and animal studies (3T MRI, PET, and microPET scanners
for human, non-human primate, and rodent scanning, an fNIRS, and an EEG recording system), as well as
expertise and tools for image acquisition and analysis; and IDD Models (Core D), providing resources, expertise,
and technical services in cellular and molecular neuroscience, the generation and manipulation of human
pluripotent stem cell (hPSC) lines from humans with IDD conditions, as well as the generation and behavioral
phenotyping of mutant or genetically engineered strains of mice and rats as models of IDD conditions. In addition,
we request support for a Research Project that addresses a fundamental question on the emergence of ADHD
symptoms in children with ASD, using a multidisciplinary approach that combines the power of neurobehavioral,
brain imaging, statistical genomics, and machine learning analyses.
We propose to provide core support to 69 research projects headed by 44 PIs addressing three broad themes
relevant to IDD: 1) neurodevelopment and mechanisms, 2) disorders of the nervous system, and 3) assessments
and interventions. Collectively the core services and the research project of the Waisman Center IDDRC will
stimulate new interdisciplinary IDD research and enhance existing IDD investigations, with a sharp focus on
discovery, prevention, and treatment for IDD conditions, and improvement of the quality of life of individuals with
IDD and their families.
我们寻求魏斯曼中心智力和发育障碍研究中心的持续支持,
专注于 IDD 的综合性跨学科项目,涵盖生物学、行为学和生物医学领域
科学。 Waisman IDDRC 汇集了来自威斯康星大学麦迪逊分校 24 个学术部门的 60 名 PI
医学与公共卫生学院、兽医学院、农业与生命科学学院、文学与科学学院、
教育、工程、社会工作和人类生态学。此应用程序请求支持
行政核心(核心 A),提供科学领导、项目和教师发展、促进
跨学科合作、培训计划监督、生物统计和生物信息学专业知识;和
传播知识和最佳实践;以及三项创新科学核心服务:临床
转化(核心 B),在招募人类参与者方面提供服务、资源和培训,
临床研究协调/导航、临床评估、行为方法开发和生产
用于临床试验的临床级生物治疗药物;脑成像(核心 C),提供了解最新状态的信息
用于人类和动物研究的最先进的神经影像仪器(3T MRI、PET 和 microPET 扫描仪
用于人类、非人类灵长类动物和啮齿动物扫描、fNIRS 和 EEG 记录系统),以及
图像采集和分析的专业知识和工具;和 IDD 模型(核心 D),提供资源、专业知识、
细胞和分子神经科学、人类神经细胞的生成和操纵方面的技术服务
来自患有 IDD 疾病的人类的多能干细胞 (hPSC) 系,以及生成和行为
对作为 IDD 病症模型的突变或基因工程小鼠和大鼠品系进行表型分析。此外,
我们请求支持一个研究项目,该项目解决了多动症出现的基本问题
使用结合神经行为学力量的多学科方法来治疗自闭症儿童的症状,
脑成像、统计基因组学和机器学习分析。
我们建议为 44 名 PI 领导的 69 个研究项目提供核心支持,涉及三大主题
与 IDD 相关:1) 神经发育和机制,2) 神经系统疾病,以及 3) 评估
和干预措施。魏斯曼中心 IDDRC 的核心服务和研究项目将共同
刺激新的跨学科 IDD 研究并加强现有的 IDD 调查,重点关注
IDD 病症的发现、预防和治疗,以及改善 IDD 患者的生活质量
IDD 和他们的家人。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Qiang Chang', 18)}}的其他基金
Waisman Center Intellectual and Developmental Disabilities Research Center
魏斯曼中心智力与发育障碍研究中心
- 批准号:
10450728 - 财政年份:2021
- 资助金额:
$ 122.68万 - 项目类别:
Waisman Center Intellectual and Developmental Disabilities Research Center
魏斯曼中心智力与发育障碍研究中心
- 批准号:
10678922 - 财政年份:2021
- 资助金额:
$ 122.68万 - 项目类别:
Waisman Intellectual and Developmental Disabilities Research Center
韦斯曼智力和发育障碍研究中心
- 批准号:
10005046 - 财政年份:2016
- 资助金额:
$ 122.68万 - 项目类别:
Waisman Intellectual and Developmental Disabilities Research Center
韦斯曼智力和发育障碍研究中心
- 批准号:
9544725 - 财政年份:2016
- 资助金额:
$ 122.68万 - 项目类别:
Waisman Intellectual and Developmental Disabilities Research Center
韦斯曼智力和发育障碍研究中心
- 批准号:
9355655 - 财政年份:2016
- 资助金额:
$ 122.68万 - 项目类别:
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