Waisman Center Intellectual and Developmental Disabilities Research Center

魏斯曼中心智力与发育障碍研究中心

• 批准号: 10239776
• 负责人: Qiang Chang
• 金额: $ 122.68万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10239776
• 关键词: Address; Agriculture; Animals; Attention deficit hyperactivity disorder; Award; Behavioral; Bioinformatics; Biological; Biological Response Modifier Therapy; Biological Sciences; Biometry; Brain imaging; Child; Clinical; Clinical Research; Clinical Trials; Clinical assessments; Cognitive Therapy; Communities; Consultations; Development; Diagnostic Services; Ecology; Educational workshop; Electroencephalography; Engineering; Environment; Exposure to; Faculty; Family; Fellowship; Fostering; Funding; Generations; Genetic Engineering; Genomics; Health Services Research; Home; Human; Human Cell Line; Imaging Device; Individual; Institutes; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Intervention; Investigation; Joints; K-Series Research Career Programs; Knowledge; Laboratories; Language Disorders; Letters; Liquid substance; Location; Machine Learning; Magnetic Resonance Imaging; Mentors; Methods; Mission; Modeling; Molecular; Mouse Strains; National Institute of Child Health and Human Development; Neurosciences; Nursery Schools; Participant; Pathology; Positron-Emission Tomography; Prevention; Privatization; Production; Productivity; Program Development; Public Health; Quality of life; Rattus; Request for Applications; Research; Research Personnel; Research Project Grants; Resources; Rodent; Scanning; Schools; Science; Scientific Advances and Accomplishments; Scientist; Seasons; Series; Services; Social Work; Sum; Symptoms; System; Teacher Professional Development; Techniques; Time; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Veterinary Medicine; Wisconsin; autistic children; base; behavioral phenotyping; biobehavior; collaborative approach; college; community clinic; cost effective; design; experience; human pluripotent stem cell; innovation; instrumentation; interdisciplinary approach; interdisciplinary collaboration; leadership development; medical schools; meetings; method development; microPET; mutant; nervous system disorder; neurobehavioral; neurodevelopment; neuroimaging; next generation; nonhuman primate; post-doctoral training; pre-doctoral; programs; recruit; science education; special interest group; stem cells; training opportunity; translational research program; treatment services; undergraduate student

We seek continued support of the Waisman Center Intellectual and Developmental Disabilities Research Center, a comprehensive interdisciplinary program focused on IDD spanning the biological, behavioral, and biomedical sciences. The Waisman IDDRC brings together 60 PIs from 24 academic departments from the UW-Madison’s Schools of Medicine and Public Health, Veterinary Medicine, Agriculture and Life Sciences, Letters and Science, Education, Engineering, Social Work, and Human Ecology. This application requests support for an Administrative Core (Core A), providing scientific leadership, program and faculty development, facilitation of interdisciplinary collaboration, oversight of training programs, biostatistical and bioinformatics expertise; and dissemination of knowledges and best practices; and three innovative scientific core services: Clinical Translational (Core B), providing services, resources, and training in the recruitment of human participants, clinical research coordination/navigation, clinical assessment, behavioral methods development, and production of clinical grade biotherapeutics for use in clinical trials; Brain Imaging (Core C), providing access to state-of- the-art neuroimaging instrumentation for both human and animal studies (3T MRI, PET, and microPET scanners for human, non-human primate, and rodent scanning, an fNIRS, and an EEG recording system), as well as expertise and tools for image acquisition and analysis; and IDD Models (Core D), providing resources, expertise, and technical services in cellular and molecular neuroscience, the generation and manipulation of human pluripotent stem cell (hPSC) lines from humans with IDD conditions, as well as the generation and behavioral phenotyping of mutant or genetically engineered strains of mice and rats as models of IDD conditions. In addition, we request support for a Research Project that addresses a fundamental question on the emergence of ADHD symptoms in children with ASD, using a multidisciplinary approach that combines the power of neurobehavioral, brain imaging, statistical genomics, and machine learning analyses. We propose to provide core support to 69 research projects headed by 44 PIs addressing three broad themes relevant to IDD: 1) neurodevelopment and mechanisms, 2) disorders of the nervous system, and 3) assessments and interventions. Collectively the core services and the research project of the Waisman Center IDDRC will stimulate new interdisciplinary IDD research and enhance existing IDD investigations, with a sharp focus on discovery, prevention, and treatment for IDD conditions, and improvement of the quality of life of individuals with IDD and their families.

我们寻求魏斯曼中心智力和发育障碍研究中心的持续支持， 专注于 IDD 的综合性跨学科项目，涵盖生物学、行为学和生物医学领域 科学。 Waisman IDDRC 汇集了来自威斯康星大学麦迪逊分校 24 个学术部门的 60 名 PI 医学与公共卫生学院、兽医学院、农业与生命科学学院、文学与科学学院、 教育、工程、社会工作和人类生态学。此应用程序请求支持 行政核心（核心 A），提供科学领导、项目和教师发展、促进 跨学科合作、培训计划监督、生物统计和生物信息学专业知识；和 传播知识和最佳实践；以及三项创新科学核心服务：临床 转化（核心 B），在招募人类参与者方面提供服务、资源和培训， 临床研究协调/导航、临床评估、行为方法开发和生产 用于临床试验的临床级生物治疗药物；脑成像（核心 C），提供了解最新状态的信息 用于人类和动物研究的最先进的神经影像仪器（3T MRI、PET 和 microPET 扫描仪 用于人类、非人类灵长类动物和啮齿动物扫描、fNIRS 和 EEG 记录系统），以及 图像采集和分析的专业知识和工具；和 IDD 模型（核心 D），提供资源、专业知识、 细胞和分子神经科学、人类神经细胞的生成和操纵方面的技术服务 来自患有 IDD 疾病的人类的多能干细胞 (hPSC) 系，以及生成和行为 对作为 IDD 病症模型的突变或基因工程小鼠和大鼠品系进行表型分析。此外， 我们请求支持一个研究项目，该项目解决了多动症出现的基本问题 使用结合神经行为学力量的多学科方法来治疗自闭症儿童的症状， 脑成像、统计基因组学和机器学习分析。 我们建议为 44 名 PI 领导的 69 个研究项目提供核心支持，涉及三大主题 与 IDD 相关：1) 神经发育和机制，2) 神经系统疾病，以及 3) 评估 和干预措施。魏斯曼中心 IDDRC 的核心服务和研究项目将共同 刺激新的跨学科 IDD 研究并加强现有的 IDD 调查，重点关注 IDD 病症的发现、预防和治疗，以及改善 IDD 患者的生活质量 IDD 和他们的家人。