Search for Antifungal Substances from Marine Invertebrates

海洋无脊椎动物，主要是海绵和腔肠动物(143个标本)已从伊豆半岛、八条岛、基伊半岛和四国海岸采集，并检测了其对白色念珠菌、拉曼被孢霉和产黄青霉的抗真菌活性。从活性海绵中分离得到了9种抗真菌物质，其结构主要通过光谱分析确定：Petrosynol(1)来自海绵Petrosia sp.在八叶岛采集到的刺果内酯A(2)和B(3)，从伊豆半岛采集的柳珊瑚(Acalycigorgia Inmis)中分离到的A(2)和B(3)，从龙眼海绵(Acalycigorgia sp.)中采集到的人参烯(Ginamallene)、A‘(5)和C(6)，以及在Kii半岛采集的Mycale属海绵中分离到的A-C(7-9)。

Marine invertebrates, mainly sponges and coelenterates (143 specimens) have been collected from various places including Izu peninsula, Hachijo Island, Kii Peninsula and Shikoku coasts, and examined for antifungal activity against Candida albicans, Mortierella ramannianus and Penicillium chrysogenum. Many sponges were found to be promising as a source of antifungal agents.The following 9 antifungal substances have been isolated from active specimens and their structures elucidated mainly by spctroscopic analyses: Petrosynol (1) from a sponge Petrosia sp. collected in Hachijo Island, acalycixeniolides A (2) and B (3) from the gorgonian Acalycigorgia inermis collected in Izu Peninsula, ginamallene (4), acalycixeniolides B' (5) and C (6) from Acalycigorgia sp., and mycalolides A - C (7 - 9) from a sponge of genus Mycale collected in Kii Peninsula.KA