EFFECT OF THE ORGANS AND TISSUES IN THE SPLANCHNIC AREA ON THE BIODEGRADATION OF HALOTHANE

用1%氟烷麻醉狗，取胃、肠和大网膜，连续10天测定尿氟和胆汁中氟的排泄量。摘除的器官重量仅相当于体重的7%。然而，与对照组相比，氟烷的吸收量减少了19%。尿氟排泄量较对照组减少58%，胆汁氟排泄量与对照组无明显差异。由此可见，内脏器官特别是脂肪组织在氟烷生物降解中起着重要作用，胆汁中的降解物质可能与尿液中的降解物质不同。

Fluoride excretions in urine and bile were measured for 10 days after 3 hours of 1% halothane anesthesia in dogs whose stomach, intestine and omentum had been removed surgically. The weight of the removed organs was corresponded to only 7% of the body weight. Nevertheless, an amount of halothane absorbed was reduced by 19% compared to that in the control group. While urinary fluoride excretion was reduced by 58% compared to that in the control group, biliary fluoride excretion in bile did not differ from that in the control.From the above results, an important role of the splanchnic organs, especially the adipose tissues, on the biodegradation of halothane was clearly realized and the degradated substance excreted in the bile might be supposed to be not similar with that in urine.