Studies on immunopathological, epidemiological analysis and control of schistosomiasis japonica in the endemic・area around Dong-ting lake.

新选择的疫源地为：（A）高流行区;（B）低流行区;（C）近控制区。虫卵阳性率A区为65.4%，B区为12.2-18.3%，C区为0%。在（C）中，血清学试验（COPT和IHA）的阳性率为6.5%。部分携带虫卵者在吡喹酮治疗前后进行了ELISA血清学检测。在治疗的六个月内，发生了针对卵抗原的抗体滴度的显著降低。对三种灭螺剂进行了室内和现场灭螺效果的研究。其中杀螟丹在田间试验中表现出较高的活性。同时对媒介钉螺的原虫寄生情况进行了调查，以达到生物防治的目的。我们调查了中国患者抗虫卵抗体独特型的异质性。检测血清样品体外激活的溶酶体特异性T淋巴细胞。提示部分患者体内存在调节性独特型抗体，该试验对分析血吸虫病免疫病理机制有一定意义。本文对中日两国血吸虫病和B型肝炎相关性肝癌的病理特点进行了比较研究。

The newly selected foci were: (A) high prevalent area; (B) low prevalent one; and (C) nearly controlled one. The positive rates of the Schistosoma japonicum egg were 65.4%, 12.2-18.3% and 0% in areas (A), (B) and (C), respectively. In (C), the positive rate of 6.5% was obtained as a result of serological tests (COPT and IHA). Some of the people with the eggs were serologically tested by means of ELISA before and after the treatment with praziquantel. Within six months of the treatment, there occurred a remarkable decrease of the antibody titer against the egg antigen. Three kinds of molluscicides were investigated for their effects in laboratories and fields. Cartap among them showed high activity in field trials. The protozoan parasites of vector snails were also investigated for the purpose of biological control. We investigated heterogeneity of idiotypes of anti-egg antibodies in Chinese patients. The serum samples were tested for activating schistosome-specific T lymphocyte in vitro. The result suggests that there is a regulatory idiotypic antibodies in some patients and that the test seems useful for the analysis of immunopathological mechanisms in schistosomiasis japonica. Pathological features of hepatic carcinoma related to schistosomiasis and hepatitis B were studied on the patients both in China and in Japan.