The Development of Human Engineering Therapeutic Equipments for Respiratory Muscle Fatigue

为提高呼吸肌疲劳患者的生活质量，1988~1990年连续3年致力于研制便携式氧分配器和便携式需求式负压呼吸机作为人体工程化治疗设备。一项同时使用这些医疗设备的临床研究表明，它们对于因呼吸肌疲劳而导致慢性呼吸衰竭的患者的家庭护理是有用的。便携式氧气浓缩器包括一个内置电容式压力传感器的通风同步器。由于浓缩器恒定流量的增加，SaO_2水平有所提高。便携式需求式负压呼吸机该设备由胸壁套装、呼吸同步器和驱动系统组成。电源可以是交流、直流电池或汽车电池。它可以很容易地使用肩带或附带的载体(总重量：约6公斤)。The Effica…在慢性呼吸衰竭患者中，评估该呼吸机的效果更好。对呼吸困难程度(Borg评分)、血氧饱和度(SaO2)、VO2/VE.3等参数均有改善作用。同时使用便携式聚氧机和便携式需氧式负压呼吸机的疗效观察首次使用便携式聚氧器治疗慢性呼吸衰竭患者吸入1h对血氧饱和度的影响。其次，对同一患者同时使用便携式氧气浓缩器和便携式需氧式负压呼吸机及呼吸机同步器的效果进行评估。使用便携式呼吸机后SaO2较使用前有较大幅度的改善，说明两种医疗设备存在协同作用。1990年10月17日，便携式氧气浓缩机被日本厚生福利省批准为《药剂法》规定的医疗设备。1990年12月13日，日本专利局公布了便携式需求型负压呼吸机的专利申请。较少

Efforts were made for 3 years from 1988 to 1990 to develop portable oxygen concentrator and a portable-demand type negative pressure ventilator as human engineering therapeutic equipment in order to improve the qualith of life for patients with respiratory muscle fatigue. A clinical study on concurrent use of these medical equipments showed that they were useful for the home care to patients with chronic respiratory failure due to respiratory muscle fatigue.1. portable oxygen concentratorA ventilatory synchronizer with a built-in capacitance-type pressure sensor was included. SaO_2 levels were improved as a result of increase in the constant flow from the concentrator.2. portable-demand type negative pressure ventilatorThis equipment consists of a chest wall suit, ventilatory synchronizer and the driving system. The power source may be AC, DC batteries or automobile batteries. It can be easily carried using a shoulder strap or the attached carrier (total weight : about 6kg). The effica … More cy of this ventilator was evaluated in the patients with chronic respiratory failure. Beneficial effects were observed on parameters such as the degree of dyspnea (Borg score), SaO_2, and Vo_2/V_E.3. Efficacy of concurrent use of the portable oxygen concentrator and the portable-demand type negative pressure ventilatorEffects of 1-hr inhalation on SaO_2 was evaluated for the patients with chronic respiratory failure using firstly the portable oxygen concentrator alone. Secondly effects of the concurrent use of the portable oxygen concentrator and the portable-demand type negative pressure ventilator with a ventilatory synchronizer were then evaluated in the same patients. Greater improvement of SaO_2 was observed after than before use of the portable ventilator, indicating the presence of synergistic effects of the two medical equipment.The portable oxygen concentrator was approved as a medical equipment under the Pharmaceutical Affairs Law by the Japanese Ministry of Health and Welfare on October 17, 1990. An patent application for the portable-demand type negative pressure ventilator was published by the Japan Patent Office on December 13, 1990. Less