Control of Organ Specific Metastasis

转移可以被认为是一个非随机过程。恶性肿瘤的增殖是以细胞的内在自主性为基础的。由宿主产生的抑制因子在恶性肿瘤的生长控制中可能起不到那么重要的作用，因为肿瘤细胞的自主增殖是内部编程的。多细胞生物体的调控机制本质上是维持细胞社会。此外，肿瘤的异质性是由细胞的内部进化引起的。肿瘤标志物一般不能预测预后，因为预后因素很复杂。然而，在癌症筛查试验中，标志物的诊断价值实际上很高。联合使用独立标记物适合诊断，因为使用独立标记物可以排除假阳性结果。

Metastasis may be considered to be an no-stochastic process. Proliferation of malignant tumors is based on a internal autonomy of cells. Suppressor factors which are produced by host may not play so important roles in growth control of malignant tumors, since autonomic proliferation of tumor cells is programmed internally. Control mechanism in multicellular organisms is essentially to maintain cell society. Furthermore, tumor heterogeneity is induced by internal evolution of cells.Tumor markers do not demonstrate prognosis in general, since prognostic factors are complicated. However, the diagnositc value of markers is practically high in screening test for carcinomas. Combination of independent markers is suitable for the diagnosis of them, since false positive results may be excluded using independent markers.