Investigations into the antibacterial mechanism of action of cannabidiol

大麻二酚(CBD)来自一系列自然产生的化合物，在主流文化中有广泛的应用。我们最近报道了CBD具有优异的抗菌性能，具有杀灭细菌的能力。该项目旨在通过在遗传和分子水平上研究CBD与细菌的相互作用来了解CBD是如何工作的。通过了解CBD如何作用于细菌细胞和在细菌细胞内，我们可以创造基本的新知识，从而设计出可以治疗细菌感染的CBD的改进类似物。作为一种急需的全新抗生素类别，这将带来显著的好处，支持澳大利亚应对抗菌素耐药性带来的挑战的国家战略。

Cannabidiol (CBD) comes from a set of naturally occurring compounds, with a range of applications in mainstream culture. We have recently reported that CBD has excellent antimicrobial properties, with the ability to kill bacteria. This project aims to understand how CBD works by examining CBD-bacterial interactions at a genetic and molecular level. By understanding how CBD acts on and within bacterial cells, we can create fundamental new knowledge that could lead to the design of improved analogs of CBD to that can treat bacterial infections. As a much-needed completely new antibiotic class, this will lead to significant benefits, supporting Australia's National Strategy to combat the challenges posed by antimicrobial resistance.