Studies on Risk Factors of Stomach Cancer and Lung Cancer in People's Republic of China

尽管国际上许多研究者做出了巨大的努力，但癌症的发生原因和癌变机制仍未完全解决。随着时间的推移，癌症教师的变化可能对这些延缓治疗起到一定的作用。对疾病流行地区和非流行地区的病因进行比较研究，是流行病学研究的基本方法之一。我国东北地区肿瘤的发生有一个有趣的特点，即农村胃癌发病率高，城市肺癌发病率高。这些特点为癌症流行病学研究提供了良好的研究领域。为了解决胃癌和肺癌的一些遗留问题，在这一领域进行了两项病例对照研究；一个是针对城市地区的肺癌，一个是针对农村地区的胃癌。以下是两项研究的主要结果：为明确胃癌高发区胃癌的主要致病因素，本文对辽宁省农村地区288例胃癌新诊断患者（男性266例，女性62例）与576名健康对照者进行了年龄、性别匹配的比较。胃癌患者表现出愤怒进食（RR=3.39）、易怒（RR=2.13）、开朗（RR=0.62）、易激动（RR=1.80）、冷漠（RR=1.47）等典型心理特征。提示心理因素可能在胃癌发生过程中起重要作用。为明确沈阳市肺癌高发区100例新诊断女性肺癌患者的组织学类型，并与年龄、性别匹配的200例健康对照进行比较。吸烟是肺癌最主要的致病因素（RR=2.1），国际上已有研究表明。肺癌合并鳞状细胞癌患者与吸烟习惯的相关性较其他类型肺癌患者强（RR=2.9）。少

In spite of big efforts of many researchers in the world, the causes of cancer and the mechanism of carcinogenesis have not been solved completely. The changing feachers in cancer with the passage of time may play some role these delay of the solution. It is one of the basic methods in epidemiologic research for getting the causes of a disease to do a comparative studies both in endemic area and in not endemic area of the disease. In the northern-east part of People Republic of China shows and interesting feature of the cancer occurrence, i. e. the frequency of stomach cancer is high in rural area and that of lung cancer in urbern area. These peculiar characteristics provide us for good field of cancer epidemiology.To solve some remained questions of stomach cancer and lung cencer, two case-control studies were conducted in this area ; one is for lung cancer in urbern area and the other for stomach cancer in rural area. Main results from these two studies are followed ;To clarify the c … More ausative factors to stomach cancer in high incidence area of stomach cancer, 288 newly diagnosed stomach cancer patients (266 males and 62 females) in rural area in Liaoning Province, China, were compared with those of age and sex matched 576 healthy controls. Patients with stomach cancer showed some typincal psychological features such as eating with angrily feeling (RR=3.39), irritable (RR=2.13), cheerful (RR=0.62), excitable (RR=1.80) and cold-hearted (RR=1.47). These results sugested that osycological factors might play some important roles in carcinogenesis of stomach cancer.To clarify the risk factors to lung cancer by histological types in Shenyang city, high incidence area of lung cancer, 100 newly diagnosed female lung cancer patients, were compared with those of age and sex matched 200 healthy controls. Smoking is the most causative factor (RR=2.1) for lung cancer as already showed in study in other area in the world. Lung cancer patients with squamous cell-carcinoma showed stronger relation to smoking habits (RR=2.9) than the other types of lung cancer patients. Less