Evaluation of liver graft viability in human liver transplantation.

通过测量动脉血酮体比率(AKBR)，对汉诺威医学院(MHH)40例脑死亡供者和京都大学(京都)31例活体供者的人肝移植术后早期存活率进行了评估。40例MHH脑死亡患者中，35例术后1周存活，5例移植肾无功能，术后1周死亡。两组AKBR均值分别为1.10和0.44，P<0.01。5例INF患者A-I(BR)均在0.7以下。在京都活体供者的31例中，第一周全部存活，AKBR值几乎都在1.0以上，平均值为1.85&lt；-+&0.23。66例患者中，AKBR>0.7者的存活率显著高于AKBR<0.7者(100%vs.42%，P&lt；)。提示AKBR可作为评价供肝存活率的有效科学标准。

Viability of the donor liver was assessed with regard to the early postoperative survival in human liver transplantations from 40 brain-dead donors in Hannox-er Medical College (MHH) and 31 living donors in Kyoto University (KYOTO) by measuring arterial ketone body ratio (AKBR). Of 40 cases harvested from brain-dead patients in MHH, 35 cases survived the first week after operation, but 5 cases developed the initial nonfunction of the transplanted graft (INF) and died within the first week. The mean valued of AKBR of each group were 1.10<minus-plus>0.10 and 0.44<minus-plus>0.10, respectively (p<0.01). A-I (BR of the 5 INF cases were all below 0.7. Of 31 cases harvested from the living donors in KYOTO, all survived the first week, and AKBR values of them were almost above 1.0 with the mean value of 1.85<minus-plus>0.23. In total of 66 cases, survival rates of the cases whose AKBR were higher than 0.7 was significantly higher than that of the cases whose AKBR were below 0.7 (100% v. s. 42%, p<It is demonstrated that AKBR can be the effective scientific scale to evaluate the viability of the donor liver.