An Open Source Approach to Understanding an Important Parasite Ion Pump

该项目计划合成与ATP4蛋白结合的新化合物，ATP4蛋白是疟原虫中必不可少的离子泵。它计划生成一个三维地图来了解这些化合物是如何阻止ATP4发挥作用的。一些很有希望的疟疾新药以ATP4为靶点，但我们还不清楚它们是如何做到的。该项目的预期目标将使用合成化学和膜生物学的新方法，并通过允许任何人参与的在线研究方法利用全球科学投入来实现。

This project plans to synthesise new compounds that bind the protein ATP4, an essential ion pump in the malaria parasite. It plans to generate a three-dimensional map to understand how these compounds stop ATP4 from working. Several promising new medicines for malaria target ATP4, yet we do not understand properly how they do so. The project’s intended aims will be achieved using new methods in synthetic chemistry and membrane biology, and by leveraging global scientific inputs through online research methods allowing anyone to participate.