Growth of an electric stimulated perichondrium
Growth of an electric stimulated perichondrium
批准号:
02807115
负责人:
TAKAHASHI Hajime
金额:
$1.02万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (C)
财政年份:
1990
资助国家:
日本
项目状态:
已结题
起止时间:
1990 至 1992
中文摘要
耳廓畸形是由软骨畸形和发育不全引起的。小耳畸形是一种严重的耳廓畸形,L说,在日本,每2万名新生儿中就有一例小耳畸形患者。本研究的目的是建立一种利用肋软骨软骨膜重建小耳的方法。由于只切除软骨膜,未发生肋骨畸形,因此,本课题拟对软骨膜移植的基本反应进行研究。为了创造出耳廓的形状,我喜欢使用“形状记忆合金”。我从一只兔子的耳朵里取出了软骨膜。然后将软骨膜包裹在形状记忆合金周围,放置在兔背部皮下,1、2、3、6个月后从背部取出软骨膜,进行软X射线检查。我将检查形状记忆合金和电刺激软骨膜之间的组织适合性。我还将开始超过12个月的长期观察。我现在正在进行非常基本的观察,将标准的(未覆盖的)形状记忆合金放入皮下。我想把这项研究再继续几年。
英文摘要
Auricular deformity occurs from cartilages deformities and hypoplasia. Microtia is a severe auricle deformity and it is said l microtia patient per 20,000 births in Japan. My purpose for this research is the establishment of the microtia reconstruction method using perichondrium of the costal cartilage. Because of only perichondrium removal, no costal deformity occurs.In point of view, I would like to do research about fundamental reaction of transplanting perichondrium. To create the shape of an Auricle; I like to use "Shape Memory Alloys". I removed perichondrium from a rabbit's ear. Then the perichondrium is wrapped around the shape Memory Alloy and placed subcutaneously into the rabbit's back.Grafted perichondrium will be removed from the back in 1, 2, 3 and 6 months later for examination by soft X-ray. I will check the tissue adaptation between Shape Memory Alloy and electrically stimulated perichondrium. I will also start long term observations for periods greater than 12 months.I am now doing very fundamental observations of having put in the standard (uncovered) Shape Memory Alloy, subcutaneously. I would like to continue this research for a few more years.
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