NMR machine, 600 MHz

柏林洪堡大学化学系需要一台600 MHz的高频核磁共振设备来进行研究。这台新机器将取代1993年投入使用的一台利用率很高的设备。游戏机于2005年更换，制造商的维修不再得到保证。由于磁铁的老化，到目前为止还不可能连接到氦回收系统，也就是说，一个新的装置也将大大节省运行成本。此外，由于易碎性，磁体不能在-10°C以下冷却。现有高场核磁共振波谱的人员、经验和能力。许多研究小组需要该设备，他们的研究工作需要高分辨率和高灵敏度的核磁共振测量。该设备还将由研究网络框架内的特定研究小组使用。在生物有机化学领域，蛋白质结构域和核酸链被研究。因此，这一领域对测量的灵敏度和分辨率的要求非常高。此外，许多被研究的体系在核磁共振时间尺度上表现出动态行为，这也需要高频装置来研究。其中既有金属配合物，也有超分子化合物。对于计划中的测量，3通道设备至关重要。在无机化学领域，由于要测量的原子核的带宽很高，通常需要三个通道，所以必须进行关联和去耦合实验。特别是在低伽马核领域(例如，对于103Rh)，灵敏度起着至关重要的作用，即使在从1H、19F或31P等更敏感的核施加磁化转移时也是如此。对于蛋白质结构域和核酸的常见三重共振实验的测量，也必须使用三通道光谱仪。

The department of chemistry of the Humboldt Universität zu Berlin requires a high-frequency 600 MHz NMR device to carry out its research. The new machine will be a replacement for a very well utilised device that was commissioned in 1993. The console was replaced in 2005 and repairs by the manufacturer can no longer be guaranteed. Due to the age of the magnet, a connection to the helium recovery system has not been possible so far, i.e. a new unit would also save running costs considerably. In addition, the magnet cannot be cooled below -10°C due to its fragility. The personnel as well as the experience and competence for high-field NMR spectroscopy are existing. The device is needed by a number of research groups whose research work requires NMR measurements with high resolution and sensitivity. The device will also be used by the specified research groups within the framework of research networks. In the field of bioorganic chemistry, protein domains and nucleic acid strands are investigated. Accordingly, the requirements for sensitivity and resolution of the measurements in this area are very high. Furthermore, many of the systems to be studied exhibit a dynamic behavior on the NMR time scale, the investigation of which also requires a high-frequency device. Among them are metal complexes as well as supramolecular compounds. A 3-channel device is crucial for the planned measurements. In the field of inorganic chemistry, correlation and decoupling experiments must be carried out due to the high bandwidth of nuclei to be measured, which often require three channels. Especially in the field of low-gamma nuclei (e.g. for 103Rh), sensitivity plays a crucial role, even when applying magnetisation transfer from more sensitive nuclei such as 1H, 19F or 31P. For the measurement of common triple resonance experiments of protein domains as well as nucleic acids, a 3-channel spectrometer is also mandatory.