Endocrine Therapy for Scirrhous-Type Gastric Cancer

一般来说，硬化型胃癌的预后较差。我们报道了一些胃癌对内分泌治疗有反应。本研究探讨内分泌治疗新药物芳香化酶抑制剂对胃癌是否与乳腺癌一样有效。在体外研究中，芳香化酶抑制剂(GGS。16949A)与乳腺癌细胞一样抑制胃癌细胞增殖。芳香化酶在胃癌组织和大网膜组织中的活性与乳腺癌组织一样高。施用芳香化酶抑制剂后，胃癌雌激素水平下降。提示芳香化酶抑制剂可用于胃癌的内分泌治疗。

It is generally speaking that scirrhous type gastric cancer shows poor ptgnosis. We reported that some of gastric cancers were responded to endocrine therapy. In this study, it is examined whether new endocrinie therapy drug, aromatase inhibitor is effective for gastric cancer as breast cancer. In vitro-study, aromatase inhibitor (GGS. 16949A) inhibited gastric cancer proliferation as breast cancer cells. The activities of aromatase were high in gastric cancer tissues and omental tissues as in breast cancer tissues. After administration of aromatase inhibitors, the estrogen levels of gastric cancer decreased. These results suggest that aromatase inhibitors is useful for endocrine treatment of gastric cancer.