Effects of Tooth-Pain on the Lateral Hypothalamus, the feeding center

用电生理学和组织学方法研究了大鼠下丘脑外侧（莱亚）神经元对牙髓电刺激的反应及从牙髓到LHA的感觉投射通路。1)在LHA外侧部发现对刺激对侧下切牙牙髓有反应的IIiA神经元，这些神经元对强烈的夹尾也有反应，但对非葡萄糖刺激无反应。2)将WGA-HRP注入LHA外侧部后的组织学研究显示，中脑室周灰质（FVG）腹侧部有许多逆行标记神经元。3)FVG神经元对刺激LHA和对侧下切牙牙髓有逆向反应。4)将WGA-HRP注入FVG的腹侧部分后，在对侧三叉神经核脊束尾侧亚核（NTST）中发现了许多标记细胞。因此，FVG是最有可能的伤害性信息从切牙到LHA的传递中继的网站。

The response of the rat lateral hypothalamic(LEA)neurons to tooth pulp electrical stimlation and the sensory projection pathway from the inusor pulp to the LHA were studied by electrophysiology and histology. 1)IIiA neurons that responded to contralateral lower incisor pulp stimulation were found in the lateral part of the LHA, These neurons also responded to intensive tail pinch, but not to innocuous stimuli nort appliedglucose. 2)Histological study after infection of WGA-HRP into the lateral part of the LHA revealed many retrogradely labeled neurons in the ventral part of the periventricular gray(FVG)in the mesencephalon. 3)The FVG neurons responded antidromically to LHA stimulation and-tb contralateral lower incisor pulp stimulation. 4)After injection of WGA-HRP into the ventral portion of the FVG many labeled cells were found in the contralateral subnucleus caudalis in the spinal tract of the trigeminal nucleus(NTST)where termination of the pulpal afferent was previously reported. It is thus suggested that the FVG is the most likely site of transmission relay of nociceptive inputs from incisors to the LHA.