Bioinorganic Chemistry on Vanadium Complexes possessing Anti-diabetic Action

我们研究了对大鼠毒性小于钒酸盐的钒基离子是否对链脲佐菌素（STZ）诱导的糖尿病大鼠具有胰岛素样作用。STZ诱导的糖尿病大鼠每天腹腔注射硫酸钒基或每天腹腔注射钒基配合物如钒基半胱氨酸甲酯（V-Cys），其血糖水平在2天内降至正常水平，并持续12周。这些治疗并没有影响他们的低血浆胰岛素水平。定量电子自旋共振（ESR）光谱分析表明，它们组织中的大部分钒（-90%）以钒基形式存在（VO^<2+>）。钒处理加速了大鼠脂肪细胞中葡萄糖的掺入，表明钒离子的作用是外周的。这些结果包括V-Cys在口服时表现出抗糖尿病作用，表明钒基复合物有可能在临床上用于治疗糖尿病

We investigated whether vanadyl ion, which is less toxic than vanadate to rats, has an insulin-like effect in rats with streptozotocin (STZ) -induced diabetes. When rats with STZ -induced diabetes were given a daily i. p. injection of vanadyl sulfate or a daily p. o. admistration of vanadyl complexes like vanadyl-cysteine methyl ester (V-Cys), their blood glucose levels decreased to the normal level within 2 days and remained low for 12 weeks. These treatments did not affect their low plasma insulin levels. Quantitative electron spin resonance (ESR) spectrometry showed that most of the vanadium(-90%)in their tissues was present as a vanadyl form (VO^<2+>). Vanadium treatments accelerated glucose incorporation into adipocytes of rats suggesting that the action of vanadyl ion is peripheral. These results including that V-Cys showed anti-diabetic action when it was given orally, suggest that the vanadyl complexes are possible to use clinically to treat diabetes