Total Synthesis of Biologically Active Compounds derived from

近年来天然产物化学的发展揭示了一些海洋天然产物的结构和生物活性。我们对它们适合大规模生产的高效合成非常感兴趣，并对它们的生物学特性进行了详细的研究。在本研究中，我们重点研究了从海绵中分离的calyculins和theonellamide f的合成。将calyculins分子分成4个片段，其中3个片段是立体选择性合成的。我们现在正在合成剩余的片段并构建整个分子。茶酰胺F是一种双环十二肽，含有多种不寻常的氨基酸。我们首先合成了这些氨基酸，然后完成了南半球和北半球的合成。我们现在正在构建来自南半球的整个甲酰胺F分子。

Recent developments of natural products clemistry have unveiled structures and biological activities of some marine natural products. We have quite interested in their efficient synthesis suitable for the large scale production to investigate their biological profiles in detail. In this research, we have focused our attention to the synthesis of calyculins and theonellamide Fisolated from marine sponges.The molecule of calyculins was divided into four fragments, three of which were synthesized stereoselectively in an efficient manner. We are now synthesizing the remaining fragment and constructing the whole molecule.Theonellamide F, a bicyclic dodecapeptide, contains various unusual amino acids. We first synthesized these amino acids, and then accomplished the synthesis of both the southern and northern hemispheres. We are now constructing the whole molecule of theonellamide F from the southern hemisphere.