Studies on cofactors for development of acquired immunodeficiency syndrome in feline immunodeficiency virus infection.

对自然感染猫免疫缺陷病毒（FIV）的11只无症状携带猫进行了长期临床观察，导致4只动物疾病进展，包括2只死亡。为了回答为什么只有一小部分自然感染的猫在给定的时间段内发病，或者为什么实验接种的动物都没有发展出终末期AIDS疾病的问题，尝试通过使用免疫抑制或免疫调节剂药物和继发性病毒感染来进行感染的实验操作。皮质类固醇，血清胸腺因子，或减毒活牛痘病毒的administration在加强猫与FIV-Petaluma株的实验感染没有效果。一些免疫增强作用，如通过CD 4阳性细胞的定量测定所确定的，在感染二次牛痘病毒感染的猫中被证明。接下来，为了研究病毒分离株之间的差异，将日本分离株FIV接种到5只SPF猫中。五分之三的猫在两年内死于艾滋病样疾病。在使用相同猫品种在相同环境中完成这些实验后，表明病毒的致病性而不是环境辅因子可能是在猫中产生终末免疫缺陷的重要决定因素。

A long-term clinical observation of 11 asymptomatic carrier cats naturally infected with feline immunodeficiency virus (FIV) resulted in disease progression in 4 animals including 2 mortalities. In order to answer the question why only a small proportion of naturally infected cats develop illness during a given period of time, or why none of the experimentally inoculated animals has ever developed terminal AIDS illness, experimental manupilation of infection by use of immunosuppressive or immunomodifier drugs and secondary viral infection was attempted. Addiministration of corticosteroid, serum thymic factor, or live attenuated vaccinia virus had no effect in potentiating the experimental infection of cats with FIV-Petaluma strain. Some immunoenhancing effect, as determined by a quantitative assay of CD4 positive cells, was demonstrated in infected cats with secondary vaccinia virus infection. Next, in order to study the difference among virus isolates, a Japanese isolate FIV was inocluated into 5 SPF cats. Three of 5 cats died within 2 years with AIDS-like illnesses. After completing these experiments in the same environment using the same cat breed, it was indicated that pathogenicity of the virus rather than environmental cofactors may be an important determinant in producing the terminal immunodeficiency in cats.