Studies on ethanol absorption from the intestine

用犬空肠段研究了乙醇和乙醛对乙醇在肠道吸收的影响。与对照组和吡唑预处理组相比，氰胺预处理组出现极高的乙醛浓度，显示门静脉血乙醇逐渐增加，吸收的乙醇量减少25%，吸收速率恒定值减少85%。这些事实表明，血液中高乙醛浓度的存在导致乙醇吸收的减少和乙醇到达体循环的延迟。与其他两组相比，在氰胺预处理组中观察到门静脉血流量的快速减少和门静脉中较低的乙醇水平，也表明乙醇通过吸收部位向血液渗透的减少是乙醛诱导的重要阻滞因素。

The effects of ethanol or acetaldehyde on ethanol absorption in the intestinal tract were studied using canine jejunal segment. The cyanamide-pretreatment group, in which an extremely high acetaldehyde concentration developed, in comparison with the control and pyrazole-pretreatment group, showed a gradual increase of portal blood ethanol, a 25 % reduction in the amount of absorbed ethanol, and an 85 % smaller absorption rate constant value. These facts indicate that the presence of a high acetaldehyde concentration in the blood results in a reduction of ethanol absorption and retardation of ethanol reaching the systemic circulation. The rapid reduction of portal blood flow and the lower ethanol level in the portal vein observed in the cyanamide-pretreatment group, in comparison with the other two groups, also indicate that the reduction of ethanol permeability through the absorption site to the blood is an important retarding factor induced by acetaldehyde.