Coordination Funds

精细化学品是生产活性药物成分、聚合物、化妆品和洗涤剂添加剂的重要原料。根据绿色化学原则，即接近零浪费，设计和操作高效和可持续的过程，以生产高价值的精细化学品是一项非常艰巨的任务。它涉及几个挑战：1)基于高活性、选择性和稳定性的催化剂确定多步化学转化路径；2)选择合适的分子构建块来制造最终目标产品；3)为所有反应和分离步骤选择环境友好的溶剂；4)阐明潜在的反应机理和动力学，作为优化反应器设计和操作的先决条件。5)确定催化剂、溶剂、未转化反应物和副产物的高效分离策略；6)建立最终目标产品的强大纯化方法；7)优化设计集成反应分离系统；8)优化控制整个生产过程以确保稳定运行。提议的DFG研究单位的中心假设是，关于催化剂、溶剂、添加剂、分离材料、设备和工艺操作条件的决定应包括在一个综合设计方法中，支持同时考虑分子水平、相水平、工艺单元水平和工厂水平上所有可用的基本变量。因此，人们可以确定具有高生产率、高产品质量和低浪费的新型精细化学品生产工艺。建议的集成设计方法将被开发并用于设计和操作两种具有药学或生物活性的物质类别的多步催化合成的生产工艺：a)基于同苯丙氨酸的化合物，b)长烷基链氨基酸和氨基醇。所选择的研究方法需要来自催化、技术化学、化学工程和过程系统工程等领域的专家之间密切的跨学科合作。在此背景下，来自罗斯托克（Matthias Beller教授、Udo Kragl教授、Christoph Kubis博士）和马格德堡（Achim Kienle教授、Nora Kulak教授、Jan von Langermann教授、Heike Lorenz教授、Andreas Seidel-Morgenstern教授、Kai Sundmacher教授）的科学家组成了一个团队，他们为DFG研究部门贡献了互补的核心能力。

Fine chemicals are very important as raw materials for the production of active pharmaceutical ingredients, polymers, cosmetics and detergent additives. Designing and operating an efficient and sustainable process in accordance with green chemistry principles, i.e. close to zero waste, for the production of a high-value fine chemical is a very demanding task. It involves several challenges: 1) identification of a multi-step chemical transformation path based on highly active, selective and stable catalysts for each step, 2) selection of suitable molecular building blocks to make the final target product, 3) selection of environmentally friendly solvents for all reaction and separation steps, 4) elucidation of the underlying reaction mechanisms and kinetics as a prerequisite for optimal reactor design and operation, 5) identification of efficient separation strategies for catalysts, solvents, unconverted reactants and by-products, 6) establishment of powerful purification methods for the final target product, 7) optimal design of an integrated reaction-separation system, and 8) optimal control of the overall production process to ensure stable operation. The central hypothesis of the proposed DFG Research Unit is that decisions on catalysts, solvents, additives, separation materials, devices and process operating conditions should be included in an integrated design methodology, supporting the simultaneous consideration of all essential variables available on the molecular level, phase level, process unit level and plant level. Thereby one can identify novel fine chemicals’ production processes that feature high productivity, high product quality and low waste. The suggested integrated design methodology will be developed and used for the design and operation of production processes for the multi-step catalytic synthesis of two pharmaceutically or biologically active examples of substance classes: a) homophenylalanine-based compounds, and b) long alkyl chain amino acids and amino alcohols. The chosen research approach requires close interdisciplinary cooperation between experts from the fields of catalysis, technical chemistry, chemical engineering and process systems engineering. Against this background, a team of scientists from Rostock (Prof. Matthias Beller, Prof. Udo Kragl, Dr. Christoph Kubis) and Magdeburg (Prof. Achim Kienle, Prof. Nora Kulak, Prof. Jan von Langermann, Prof. Heike Lorenz, Prof. Andreas Seidel-Morgenstern, Prof. Kai Sundmacher) was formed, who contribute complementary core competencies to the DFG Research Unit.