Studies on the regulation of gene expression in lymphoid cells.

该项目的完成是为了促进日美免疫学家和分子生物学家之间的合作研究。在本项目期间，(1)两名日本成员研究员被派往美国，(2)在日本福冈举行了关于免疫调节和耐受机制的研讨会。(1)日本成员科学家被派往美国进行合作。(1)岸本博士于1992年11月29日至12月5日被派往美国。他访问了贝塞斯达的NIH，与W.E.Paul博士和T.Waldmann博士就细胞因子受体的信号机制和免疫疾病中细胞因子基因的异常表达进行了讨论。他还访问了洛杉矶的加州大学洛杉矶分校，与马丁内斯-马扎博士安排了一个关于艾滋病病理的分子生物学解剖的合作项目。(Ii)西川博士从1月1日至…被派往美国新墨西哥州的陶斯1993年2月8日，因参加B淋巴细胞分化分子方面的研讨会。在这次研讨会上，他与P.Kincade博士和D.Baltimore博士(蒙布霍研究计划的成员)以及他们的同事进行了讨论。根据Nishikawa博士提出的P53原癌基因产物在V-D-J重组时参与前B细胞细胞周期停滞的建议，他与一些美国研究人员进行了讨论，并成功地安排了这方面的合作研究。还报道了抗IL-7受体抑制抗体的制备，西川博士与美国科学家联系，利用这种抗体开始合作研究B细胞分化。(2)1993年3月2日至3月3日在福冈举行了关于免疫调节和耐受机制的研讨会。在这次研讨会上，日本和美国在这一领域的顶尖科学家做了17次演讲。在整个研讨会期间，与会者根据他们最新的知识进行了密集的讨论。除了演讲者外，100多名日本领先的免疫学家和年轻科学家响应我们的呼吁参加了会议。本次研讨会的重点是(1)淋巴细胞的激活和谱系选择，(2)淋巴细胞生成中的转录因子，(3)淋巴细胞激活中的信号转导。综上所述，本研究计划被认为是成功完成的，毫无疑问，成员研究人员在本计划的支持下，通过各自的合作取得了丰硕的成果。较少

This project has been accomplished for the purpose of promoting collaborative studies between Japanese and American immunologists and molecular biologists. During the term of this project (1) two of the Japanese member investigators were sent to the United States of America and (2) the symposium on the mechanisms of immune regulation and tolerance was held in Fukuoka, Japan.(1) Sending of Japanese member scientists to the U.S.A. for collaboration.(i) Dr.T.Kishimoto was sent to the U.S.A. from November 29 to December 5, 1992. He visited NIH in Bethesda for having discussion with Dr.W.E.Paul and Dr.T.Waldmann on the signaling mechanisms through cytokine receptors and on the aberrant cytokine gene expression in immunological disorders. He also made a visit to UCLA in Los Angeles for arranging a collaborative project with Dr.O.Martinez-Maza regarding molecular biological dissection of the pathology of AIDS.(ii) Dr.S.-I.Nishikawa was sent to Taos, New Mexico in the U.S.A. from January 1 to … More February 8, 1993 for attending the symposium on the molecular aspect of B lymphocyte differentiation. In this symposium, he discussed with Dr.P.Kincade and Dr.D.Baltimore (members of this Monbusho Research Program) as well as their colleagues. Based on Dr.Nishikawa's presentation suggesting involvement of p53 proto-oncogene product in the cell cycle arrest of pre-B cells at the V-D-J recombination, he discussed with some American researchers and has successfully arranged a collaborative study in this regard. The preparation of anti-IL-7 receptor inhibitory antibody was also reported there, and Dr.Nishikawa has made a contact with American scientists to start collaboration on B cell differentiation by the use of this antibody.(2) The symposium on the mechanisms of immune regulation and tolerance was held from March 2 to March 3, 1993 in Fukuoka. In this symposium, 17 presentations were made by Japanese and American top-ranking scientists in this field. The participants intensively made discussion based on their very recent knowledge throughout the symposium. In addition to the speakers, over a hundred Japanese leading immunologists and young scientists gathered in response to our call for participation. The symposium was focused on (I) the lymphocyte activation and repertoire selection, (II) the transcription factors in lymphopoiesis, and (III) the signal transduction in the lymphocyte activation.From the above activities and accomplishments, in conclusion, this Research Program is believed to be successfully completed and it is no doubt that member investigators have obtained fruitful results from their respective collaboration supported by this Program. Less