Newlly Development and a Clinical Application of a Novel Preservation Solution for the lung (ET-Kyoto Solution)

肺移植已被确定为终末期肺部疾病患者的一种成功的治疗选择。然而，由于缺乏合适的供肺，该技术的广泛应用受到了限制。为了克服这一局限性，我们开发了一种新的胞外或胞内类型的溶液，ET-京都或IT-京都溶液，它包含4.1%的海藻糖、葡萄糖酸盐和羟乙基淀粉(HES)。结果表明，ET-京都液保存20小时的移植肺功能明显优于IT-京都液或Euro-Collins液保存的肺。我们的结果还表明，用ET-京都液保存30h的移植肺的功能明显好于用威斯康星大学液保存的肺。在这份报告中，明确证明ET-K液是一种始终如一的优良防腐剂。希望本研究结果有助于增加供体肺的供应，并使临床肺移植领域的半选择性手术成为可能。

Lung transplantation has been established as a successful therapeutic option for patients with end-stage lung diseases. However, the the wide spread application of this proedure is limited by the shortage of suitable donor lungs. To oversome this limitation, we developed a new extra or intracellular type solution, ET-Kyoto or IT-Kyoto solution, which contains 4.1% trehalose, gluconate, and hydroxyethyl starch (HES). Our results demonstrated that the function of the transplanted lung preserved with the ET-Kyoto solution for 20 hours was significantly better than those of lungs with IT-Kyoto or Euro-Collins solution. Our results also showed that the function of the transplanted lung preserved with the ET-Kyoto solution for 30 hours was significantly better than that of lungs with the University of Wisconsin solution. In this report, it was demonstrated definitely that the ET-K solution is a consistently excellent preservative solution. It is hoped that the result of this study will contribute to an increase in the supply of donor lungs and make semielective operations possible in the field of clinical lung transplantation.