Seroepidemiological study on stomach cancer in China

为探讨萎缩性胃炎和幽门螺杆菌感染与胃癌的关系，对沈阳市中国进行了血清流行病学调查。1.对沈阳市献血员血清中胃蛋白酶原、幽门螺杆菌抗体和B-胡萝卜素进行检测，并与日本宫城地区进行比较。男性的幽门螺杆菌感染率在斯宁阳低于宫城。两地血清β-胡萝卜素水平差异无统计学意义。2.病例对照研究对沈阳地区201例胃癌患者和608例住院对照的生活方式进行访谈，并对其血样进行胃蛋白酶原和幽门螺杆菌抗体检测。胃癌家族史、吸烟、经常食用咸菜、萎缩性胃炎、幽门螺杆菌感染增加了患胃癌的风险，经常摄入咸鱼和新鲜水果增加了患胃癌的风险。这些结果表明萎缩性胃炎和幽门螺杆菌感染在个体水平上在胃癌的发生中起重要作用。

A seroepidemiological study in Shenyang City, China, was performed to examine the relation of atrophic gastritis and Helicobacter pylori infection to stomach cancer.1.Prevalence of atrophic gastritis and Helicobacter phlori infection in ChinaSerum samples, collected from blood donors in Shenyang, were analyzed for pepsinogen, lgG Helicobacter pylori antibody and B-carotene, and the results were compared to those from Miyagi, Japan, The prevalence of atrophic gestritis, determined by pepsinogen I AND II,was lower in Shenyang than in Miyagi for both sexes. The prevalence of Helicobacter pylori infection was lower in Snenyang than in Miyagi for males. The serum leves of B-carotene was not different between two areas.2.A case-control study in Shenyang201cases with stomach cancer and 608 hospital controls were interviewed concerning lifestyle and their blood samples were analyzed for pepsinogen and Helicobacter pylori antibody. Family history of gastric cancer, current smoking, frequent intake of salty pickles, atrophic gastritis and Helicobacter phylori infection were incresed the risk of stomach cancer, and frequent intake of salty fish and fresh fruits decresed. These results suggests that atrophic gastritis and Heliorcbacter pyloiinfection play an important role in carcinogenesis of stomach cancer on the individual level