Microproteins encoded by “non-coding” RNAs in vascular disease (A10*)

我们已经成功地鉴定了内皮细胞微蛋白质组，包括来自lncRNAs的微蛋白（lnc-miPs）。在这个项目中，我们将表征两种内皮细胞lncrna的编码和非编码功能，它们的表达在血管炎症反应中发生改变。我们还将测定血管疾病患者收缩性和分泌性血管平滑肌细胞的微蛋白质组，并在单培养和动脉芯片模型中研究干扰新型血管平滑肌细胞lnc-miPs表达的影响。

We have succeeded in identifying the endothelial cell microproteome, including microproteins derived from lncRNAs (lnc-miPs). In this project we will characterize the coding and non-coding function of two endothelial cell lncRNAs, whose expression is altered in response to vascular inflammation. We will also determine the microproteome of contractile and secretory vascular smooth muscle cells from patients with vascular disease and study the impact of interfering with the expression of novel vascular smooth muscle cell lnc-miPs in monoculture and an artery-on-a-chip model.