Advancing the visualisation and quantification of nephrons with MRI.

该项目旨在利用没有造影剂的磁共振成像，结合深度学习和超分辨率技术，表征肾单位、肾小球和肾小管的关键组成部分。肾单位是肾脏的基本功能单位，对维持人体的动态平衡至关重要。它们的数量和结构是肾功能的关键决定因素。预期的结果是创新的半自动肾单位可视化和量化工具，使有效的肾脏表型。为广泛使用的临床前研究扫描仪量身定做的技术预计将加快对影响胚胎和出生后肾脏微结构的遗传和环境因素的研究。

This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are innovative semi-automated nephron visualisation and quantitation tools that enable efficient renal phenotyping. Techniques tailored to widely accessible preclinical research scanners are expected to accelerate research into genetic and environmental factors affecting kidney microstructure in embryonic and post-natal life.