Development of physiological regional hepatic function test using positron emission tomography

由于肝脏具有动脉和门静脉双重血供，肝局部血流量的定量测量一直没有得到解决。然而，我们成功地同时测量区域肝动脉和门静脉血流PET在非应激患者。为了更准确地反映肝脏的生理功能，我们设计了一种新的H_2^ O正电子发射断层显像模型<15>，该模型由肝脏和门静脉系统组成，应用“曲线分析”，并引入了门体分流系数和门静脉器官内循环时间系数。本文应用H_2^<15>O动态法对121例正常人、慢性肝炎、肝硬化及其它四组病人进行了肝脏PET扫描。分别为61例、39例、16例、5例。正常人和肝硬化患者之间的显着差异，区域总，动脉，门静脉肝血流量，门体分流的比例，和门静脉器官内的血液循环时间。在正电子发射断层扫描时，它们之间的肝脏水系数也存在显著差异，这被认为是有用的肝脏新的病理生理参数。正电子发射断层扫描有利于生理性局部肝功能检查。

As the liver has dual blood supplies, arterial and portal, regional hepatic blood flow had not been measured quantitatively. However, we succeeded in simultaneously measuring both regional hepatic arterial and portal blood flow by PET in non-stressed patients. To examine the more accurate physiological function of the liver, a new model was designed for positron emission tomographic study using H_2^<15>O,which was consisted of the components of the liver and the portal system, applied "curve analysis", and introduced a portosystemic shunt factor and a coefficient for circulation time within the portal organs. PET scans of the liver were performed using the H_2^<15>O dynamic method in 121 patients which were classified into 4 groups ; normal, chronic hepatitis, cirrhosis and the others. They were consisted of 61,39,16, and 5 patients. Significant differences between normal and cirrhotic patients were noted in the regional total, arterial, portal hepatic blood flow, the ratio of porto-systemic shunting, and the circulating time within the portal organs for the blood. There was a significant differences between them also in a coefficient of the liver for water when positron emission tomographic scan, which was thought to be useful as a new pathophysiological parameter of the liver. Positron emission tomographic study was beneficial for the physiological regional hepatic function test.