Understanding the generation of hypothalamic sleep neurons

该项目旨在研究控制下丘脑睡眠神经元形成的机制。我们都在睡觉，而正常的睡眠-觉醒周期在我们的生物学中扮演着核心角色。这些睡眠神经元在成熟大脑中的功能作用已经得到了很好的证实。然而，神经元是如何在发育过程中产生的，目前还没有明确的定义。这个项目旨在解决这一关键的知识差距，并将极大地增加我们对生物功能的这一关键方面的发展是如何在发育过程中进行协调的理解。该项目还将开发在生物科学领域具有广泛用途的生物信息学工具，并加强跨学科国际合作的能力。

This Project aims to investigate the mechanisms controlling the formation of the sleep neurons in the hypothalamus. We all sleep, and normal sleep-wake cycles play a central role in our biology. The functional role of these sleep neurons in the mature brain are well established. However, how the neurons are generated during development is very poorly defined. This project aims to address this critical knowledge gap, and will greatly increase our understanding of how the development of this critical aspect of organismal function is orchestrated during development. This project will also develop bioinformatics tools with broad utility within the biosciences field and enhance the capacity for interdisciplinary international collaborations.