Mapping networks governing cell state plasticity: how, where and when?

单细胞生物体是生命的基本单位，然而，如果它们没有发展出改变细胞状态的能力，我们今天就不会存在。细胞状态的改变是多细胞生物体几乎所有发育和疾病过程的核心。在干细胞和非干细胞容易相互转换的基本发现的基础上，我们现在将结合创新的细胞系统和我们新的多层系统生物学策略的开发，以阐明对细胞状态变化背后的细胞生物学的第一个全面理解。这些研究是朝着理解生活的基本原理迈出的重要一步。

Single cell organisms are the basic unit of life, yet, if they had not developed the ability to change cell states we would not exist today. Changing cell states lies at the core of almost every developmental and disease process in multicellular organisms. Building upon our fundamental discovery that stem cells and non-stem cells readily interconvert, we will now incorporate innovative cell systems and the development of our new multi-layered systems biology strategy to elucidate the first comprehensive understanding of the cell biology that underlies cell state changes. These studies are a major step toward understanding the fundamentals of life.