System-level characterisation of the siphonophore, Indo-Pacific man o' war

印度-太平洋的人o' war（bluebottle），是一种刺胞动物，来自管水母目。这些动物成群结队地出现在澳大利亚的海滩上，每年都会造成数千起蜇伤。该项目建议对绿头苍蝇的基因组、转录组、表观基因组和蛋白质组进行分析，以深入了解其生命周期、行为和毒素。预期的成果包括产生新的信息，与绿头苍蝇基因调控及其毒素库，这将是非常有益的设计未来的刺痛治疗策略。鉴于绿头苍蝇是由功能专门化的息肉组成的群体，这项研究也将为动物多细胞的起源和进化提供重要的新见解。

The Indo-Pacific man o' war (bluebottle), is a cnidarian from the siphonophore order. These animals frequent Australian beaches in swarms and cause thousands of stings every year. The project proposes to profile the genome, transcriptome, epigenome, and proteome of the bluebottle to gain insight into its life cycle, its behaviour, and toxins. Expected outcomes include the generation of novel information related to bluebottle gene regulation and its toxin repertoire, which will be highly beneficial for the design of future sting treatment strategies. Given that the bluebottle is a colony made of functionally specialised polyps, this study will also provide significant novel insight into the origins and evolution of animal multicellularity.