Co-operative Research on Clinical Application and Functional Preservation of Heart and Heart-lung Transplantation
Co-operative Research on Clinical Application and Functional Preservation of Heart and Heart-lung Transplantation
批准号:
07307015
负责人:
NAKAJIMA Jun
金额:
$15.81万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
1995
资助国家:
日本
项目状态:
已结题
起止时间:
1995 至 1997
中文摘要
Kaihara研究了多器官共享的信息网络系统,比经典的主框架更适合实现所需的功能,特别是在互联网系统上处理信息的细节。松田研究了移植物的冠状动脉粥样硬化,在移植的头几天是预先设定的。Tabayashi和Isobe报道了ACE抑制剂、血管紧张素II受体拮抗剂、细胞周期基因诱骗和抗黏附分子可预防移植物动脉粥样硬化。Sano研究了温心停跳1小时后的供心功能。Taira报道了透明质酸酶用于增强型心脏停搏液的可行性。小柳研究了新的免疫抑制剂。Kawashima和Nakatani报告了两例内期心肌病病例。他们成功地接受了左心辅助装置的治疗,并在脱机后仍然活着。Fuuse、Takamoto和Nakajima研究了幼猴的非协调性异种心脏移植。Hujimura,Eguchi,Yada对肺保存和免疫抑制治疗进行了实验研究。
英文摘要
Kaihara investigated information Network System for multi organ sharing and more appropriate to implement required features than a classical main frame, especially the details about handling informations on inter net system. Matsuda investigated graft coronary atherosclerosis is preset in the first several days of transplantation. Tabayashi and Isobe reported ACE inhibitor, Angiotensin II receptor antagonist, cell cycle gene decoy and anti adhesion molecule prevent graft atherosclerosis. Sano investigated the donor heart Function harvested after 1 hour of warm cardiac arrest. Taira reported feasibility of hyaluronidase fo rtified cardioplegia. Koyanagi studied new immunosuppressive agent. Kawashima and Nakatani reported two endostage cardiomyopathy cases. They were successfully treated with left ventricular assist device and still alive after weaning of the device. Furuse, Takamoto, Nakajima investigated discordant xenoheart transplantation in infantile monkeys. Hujimura, Eguchi, Yada experimentally investigated lung preservation and immunosuppressive therapy.
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Sawa Y et al: "A norel strategy for myocardial protection using in vivo franefection of cis element ,'Decoy'against NFKB Binding Site" Circulation. 96. II-280-II-285 (1997)
Sawa Y 等人:“Norel 策略利用体内顺式元件‘诱饵’对抗 NFKB 结合位点进行心肌保护”循环。
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Isobe M et al: "Acceptance of primary skin graft after treatment with anti intercellular adhesion molecule-1 and anti-leucocyte function associated antigen 1 monoclonal antibodies in mice" Transplantation. 62. 411-413 (1996)
Isobe M 等人:“小鼠用抗细胞间粘附分子 1 和抗白细胞功能相关抗原 1 单克隆抗体治疗后接受原代皮肤移植” 移植。
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Suzuki J et al: "Prevention of graft coronary atherosclerosis by antisense cdk2 kinase oligonucleotide" Nature Medicine. 3. 900-903 (1997)
Suzuki J 等人:“通过反义 cdk2 激酶寡核苷酸预防移植冠状动脉粥样硬化”《自然医学》。
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Sawa Y et al: "Efficient gene transfer method into the whole heart through the coronary artery with hemagglutinating virus of Japanese liposime" J.Thorac.Cardiovasc.Surg.113(3). 512-519 (1997)
Sawa Y等人:“使用日本脂质体的血凝病毒通过冠状动脉将基因有效转移到整个心脏的方法”J.Thorac.Cardiovasc.Surg.113(3)。
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Isobe M et al: "Acceptance of primary skin graft after treatment with anti-intercellular adhesion molocule-1 and anti-leucscyte function-associated antigen-1 monoclonal antibadies in mice" Transplantation. 62(3). 411-413 (1996)
Isobe M 等人:“在小鼠中用抗细胞间粘附分子 1 和抗白细胞功能相关抗原 1 单克隆抗体治疗后接受原代皮肤移植” 移植。
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