Study on the cooperative bactericidal activities between neutrophis and antibiotics, electrolyzed-oxidizing water in serious infection disease

O_2^\->production abnormalities of neutrophils in peripheral blood with severely infectious disease in maxillofacial region were investigated by CLA dependent chemiluminescence method。The effect of antibiotics on O_2^\->production of neutrophManagement was also studied。Furthermore，电氧化水对Stapylococcus aureus （S. aureus）的细菌效应被O_2调查过^<->营养素的产生和整合素分子的表达。结果如下。O_2^<·->production of neutrophils obtained from 12 patients with Oral cancer and 6 patients with Mandublar osteomyelitis showed lower values than heal thy volunteers。12名口腔癌患者的6名患者因MRSA.2的后操作性感染而受到影响。四种抗生素（ASPC，NTL，ISP，FLRX）增加了O_2^<·->产生的中性植物以显示协同细菌活性。他们三个（ASPC，NTL，FLRX）增加了对营养素膜表面的C3 b接收器的表达。O_2^<·->用S. aureaus的噬菌体生产的营养素（1*10^8/ml） ，其中有50%的细菌被这种治疗损坏。使用phagocytosing S. aureus revealed that 70- 80%of bacteria lost their biological activities by the treatment with electrolyzed-oxidizing water.4。MRSA感染的外科伤口被显著改善了，用电氧化的水冲洗。在治疗MRSA感染患者时，吸血鬼的最佳剂量^&lt;<encircledR>&gt;是通过监测其在外围血液中的浓度来确定的。这些结果建议是有用的，因为它是基于合作活动中增加了O_2^&lt;-&gt;营养素的生产。电氧化化水显示出对小细菌的致命影响，因此，其临床用途得到了更多的推荐。

O_2^<・->production abnormalities of neutrophils in peripheral blood with severely infectious disease in maxillofacial region were investigated by CLA dependent chemiluminescence method. The effect of antibiotics on O_2^<・->production of neutrophils was also studied. Furthermore, bactericidal effects of electrolyzed-oxidizing water on Stapylococcus aureus (S.aureus) were investigated by O_2^<・->production of neutrophils and expression of integrin molecules.Results were as follows.1. O_2^<・->production of neutrophils obtained from 12 patients with oral cancer and 6 patients with mandublar osteomyelitis showed lower values than heal thy volunteers. Six of 12 patients with oral cancer were suffered from postoperative infection by MRSA.2. Four antibiotics (ASPC,NTL,ISP,FLRX) increased O_2^<・->production of neutrophils to show cooperative bactericidal activities. And three of them (ASPC,NTL,FLRX) increased the expression of C3b recepter on the suface of neutrophil membrane.13EA04 : 3. O_2^<・->production of neutrophils accompanying with phagocytesis of S.aureaus (1*10^8/ml) , which were pretreated by electrolyzed-oxidizing water, showed 50% of bacteria was injured by this treatment. The expression of integrin molecules' (CD11b and CD18) on the surface of neutrophil membrane with phagocytosing S.aureus revealed that 70-80% of bacteria lost their biological activities by the treatment with electrolyzed-oxidizing water.4. Surgical wound infected by MRSA was remarkably improved by washing with electrolyzed-oxidizing water. In treating MRSA infection patients, optimal dosage of Vancomycin^<<encircledR>>was determined by monitoring its concentration in peripheral blood.These results suggested that it was useful to choose antibiotics based on the cooperative activity which increased O_2^<・->production of neutrophils. Electrolyzed-oxidizing water showed fatal effects on peccant bacteria, therefore, its clinical use was more recommended.