Development of the new bone regeneration method by transplanting jawbone periosteum sheets as a mechanosensor.

通过移植颌骨骨膜片作为机械传感器开发新的骨再生方法。

• 批准号: 23592979
• 负责人: KIMURA Hiroto
• 金额: $ 3.24万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592979/
• 关键词: 骨膜; メカノセンサー; 骨代謝; Wnt pathway; BMP pathway; メカニカルストレス; Wnt signaling; BMP signaling; 骨リモデリング; 歯学; 移植・再生医療; 細胞・組織; 臨床; 骨増生法

The relationship between mechanical stress and osteogenesis has been widely studied. However, little is known about the functions of the periosteum in bone remodeling under mechanical stress. We hypothesized that the periosteum senses a mechanical stress to induce bone remodeling, therefore, we subjected periosteum cells to load mechanical stretching and characterized their gene expression profiles.Periosteum cells appear to induce, in response to the stretch stimulus, gene expression changes in WNT pathway and BMP pathway, which cooperate to promote osteoblast differentiation and osteogenesis. Our results also suggest that during mechanical stress-induced bone remodeling in the body, the periosterum senses the mechanical stress to control signals for promoting osteoblast differentiation and osteogenesis.

机械应力与成骨的关系已被广泛研究。然而，骨膜在机械应力下骨重建中的作用却知之甚少。我们假设骨膜感受到机械应力而导致骨重建，因此，我们对骨膜细胞进行了机械拉伸实验，并对它们的基因表达谱进行了表征，发现骨膜细胞在拉伸刺激下诱导WNT通路和BMP通路的基因表达变化，这两条通路共同促进成骨细胞的分化和成骨。我们的研究结果还表明，在机械应力诱导的骨重建在体内，骨膜感觉到机械应力，以控制信号，促进成骨细胞分化和成骨。

项目成果

Periosteum-derived cells respond to mechanical stretch and activate Wnt and BMP signaling pathways

• DOI: 10.2220/biomedres.35.69
• 发表时间: 2014-02-01
• 期刊: BIOMEDICAL RESEARCH-TOKYO
• 影响因子: 1.2
• 作者: Ito, Ryohei;Matsumiya, Tomoh;Kimura, Hiroto
• 通讯作者: Kimura, Hiroto

Usefulness of two-stage surgery for benign odontogenic tumors showing large cystic, intraosseous lesions in the mandible

两阶段手术对于下颌骨中出现大的囊性骨内病变的良性牙源性肿瘤的有用性

• 发表时间: 2012
• 作者: 孔 礼群;鈴木邦明;出山義昭;工藤智也;吉村善隆;Hiroto KIMURA
• 通讯作者: Hiroto KIMURA