Development of the new bone regeneration method by transplanting jawbone periosteum sheets as a mechanosensor.

机械应力与成骨之间的关系已被广泛研究。然而，人们对骨膜在机械应力下骨重塑中的功能知之甚少。我们假设骨膜感知机械应力以诱导骨重塑，因此，我们对骨膜细胞施加机械拉伸负荷并表征其基因表达谱。骨膜细胞似乎响应拉伸刺激而诱导WNT通路和BMP通路的基因表达变化，这共同促进成骨细胞分化和成骨。我们的结果还表明，在机械应力诱导的体内骨重塑过程中，骨膜感知机械应力以控制促进成骨细胞分化和成骨的信号。

The relationship between mechanical stress and osteogenesis has been widely studied. However, little is known about the functions of the periosteum in bone remodeling under mechanical stress. We hypothesized that the periosteum senses a mechanical stress to induce bone remodeling, therefore, we subjected periosteum cells to load mechanical stretching and characterized their gene expression profiles.Periosteum cells appear to induce, in response to the stretch stimulus, gene expression changes in WNT pathway and BMP pathway, which cooperate to promote osteoblast differentiation and osteogenesis. Our results also suggest that during mechanical stress-induced bone remodeling in the body, the periosterum senses the mechanical stress to control signals for promoting osteoblast differentiation and osteogenesis.