Development of depth dose meter for heavy ion particle beams with piled plastic scintillators
Development of depth dose meter for heavy ion particle beams with piled plastic scintillators
批准号:
07507005
负责人:
INOUE Toshihiro
金额:
$1.28万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
1995
资助国家:
日本
项目状态:
已结题
起止时间:
1995 至 1996
中文摘要
我们继续测试新研制的深度剂量计。采用大阪大学医院直线加速器的x射线(4、10和18 MV)、电子束(6、9、12和15 MeV)、大阪大学RCNP回旋加速器的质子束(65和200 MeV)和近红外光谱仪千叶医疗重离子加速器的碳束(290MeV/n)对剂量计进行了测试。在遮光方面,无热压制型纤维块比有热压制型纤维块更适合于传感器。利用数字滤波器可以在获取图像数据时减小背景信号。在补偿切伦科夫光对X射线和电子束的影响、高能质子束对光的猝灭作用后,电离室的深度剂量数据与新型剂量计的深度剂量数据吻合良好。通过补偿纤维块的光发射特性,使误差减小。我们可以测量碳单峰光束的深度剂量曲线。但对于含有不同LET成分的分散碳梁,差异很大。还有很大的改进空间。通过对变粒子发光差异的校正,确认了深度剂量计的高质量,我们计划制作更紧凑的三维深度剂量计,使探测器旋转和直线运动。这种新设计的剂量计减少了测量基本剂量分布的时间,是有用的。
英文摘要
We continued to test the new developed depth dose meter. The dosimeter was exposed to x rays (4,10 and 18 MV) and electron beams (6,9,12 and 15 MeV) from Linac at the Osaka University Hospital, proton beams (65 and 200 MeV) from the cyclotron at RCNP of Osaka University and carbon beam (290MeV/n) from the Heavy Ion of Medical Accerator in Chiba of NIRS to test it. The pressed type of fiberblock without heat is more suitable for sensor than that with heat in respect of shielding the light. We could decrease the background signal in obtaining the image data by utilizing the digital filter. The fitness was good between the depth dose data by ionization chamber and by new dosimeter after compensating Cerenkov light for X ray and electron beam, quenching of light by energetic proton beams. The discrepancy became smaller by compensating the characteristics of emission of light from fiberblock. We could measure the depth dose curve for mono peak beam of carbon. But the discrepancy was large for spread outed carbon beams containing different components of LET.There are much room for improvement. After confirming the high quality of depth dose meter by correcting the difference of light emission by variable particles, we have a plan to make more compact 3D depth dose meter with rotation and rectilinear motion of detector. Such a new designed dosimeter will be useful because of reducing time for measurement of the fundamental dose distribution.
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井上俊彦: "重粒子線照射によるcell cycle arrestに対するp53の関与" 平成7年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書. 105-106 (1996)
Toshihiko Inoue:“p53参与重离子束照射引起的细胞周期停滞”1995年国立放射线科学研究所联合使用重离子癌症治疗设备研究报告105-106(1996)。
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福島祥子: "陽子線と炭素線照射によるヒトリンパ芽球系細胞でのアポトーシス誘導" 日放腫会誌. 8(suppl 1). 280- (1996)
Sachiko Fukushima:“通过质子束和碳离子照射诱导人淋巴母细胞凋亡”,日本放射治疗学会杂志 8(增刊 1)。
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Murayama, S.: "Construction of the irradiation system for biological and medical use in RCNP (2)." RCNP Annual Report 1994. 69-71 (1995)
Murayama, S.:“RCNP 生物和医学用途辐照系统的构建 (2)”。
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Fukushima, S.: "Cell cycle kinetics and p53 protein induction in human lymphoblast cell lines following exposure to 65 MeV proton beam." RCNP Annual Report 1995. 66-69 (1996)
Fukushima, S.:“暴露于 65 MeV 质子束后人淋巴母细胞系的细胞周期动力学和 p53 蛋白诱导。”
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Fukushima, S: "Induction of p53 protein by carbon ion and proton beam irradiation in two close human lymphoblastoid cell lines with different p53 status" Oncology Reports. 4(in press). (1997)
Fukushima, S:“通过碳离子和质子束照射在具有不同 p53 状态的两种相近的人淋巴母细胞系中诱导 p53 蛋白”《肿瘤学报告》。
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共 10 条
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批准号:23791994
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.66万
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负责人:INOUE Toshihiro
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依托单位:
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负责人:INOUE Toshihiro
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