Development and Application of Highly Sensitive Medical optodes

光学化学传感器是一种通过光学转换来测量化学物种的装置，被称为“光学电极”或“光学电极”。由于光电器件的高性能，特别是在实际应用中的高灵敏度，以及化学、物理和临床领域的许多研究人员的物理化学和科学兴趣，目前正受到人们的广泛关注。在利用新开发的低损耗聚合物光纤开发基于新设计和合成的中性离子载体的高灵敏度光纤型离子选择光电器件的过程中，建立了响应模型，并对响应曲线进行了数学模拟，以阐明实验响应曲线。对于这些通过将功能分子固定在传感器膜上而开发的光电器件的应用，采用了一种称为“快速流动分析(RFA)”的新方法。在这种情况下，根据TH…讨论了响应理论利用新型pH光导和钠离子选择性光导作为离子检测探针，对由朗伯-比尔定律和费克扩散定律导出的理论方程进行了进一步的优化。因此，建立了一种兼具快速和高灵敏度离子检测(RFA)优点的新的分析方法。另一方面，设计了一种新型的高灵敏度离子检测探头--有源波导型传感器。到目前为止，所有报道的平面波导传感器都使用波导作为唯一的光传播层，然而，所开发的有源波导光导管不仅利用波导芯作为光传播层，还通过包含中性离子载体和亲油染料等功能分子作为分子识别和转换层。这种波导式传感器的一大优点是，即使使用小型化的探头也可以获得高灵敏度。利用钙离子载体和钠离子载体构建了两个有源波导型离子光电极，证实了该波导的潜在应用价值。基于逝去波光谱学的新型光波导光头与传统光波导光头的实验响应曲线比较表明，本文提出的新型光波导光头的灵敏度明显高于传统光波导光头。较少

An optical chemical sensor is a device which can measure chemical species with optical transduction, and is called "Optode" or "Optrode". Optodes are now attacting much attention due to their high performance, especially their high sensitivity in practical applications, and the physicochemical and scientific interests of many researchers in the chemical, physical, and clinical fields.In the development of a highly sensitive optical fiber-type, ion-selective optodes based on newly designed and synthesized neutral ionophores using a newly developed low-loss polymer optical fiber, the response models were proposed and mathematical simulation of the response curves were investigated in order to elucidate the experimental response curves.For the application of these optodes, which were developed with immobilizing functional molecules on the sensor membranes, a novel methodology called "Rapid Flow-through Analysis (RFA)" was used. In this case the response theory was discussed in terms of th … More e optimization of the theoretical equation which is basically derived from Lambert-Beer's law and Fick's law of diffusion, based on the experimental responses obtained by utilizing novel pH optodes and sodium ion-selective optodes as the ion detection probes. Consequently, a novel analytical methodology was established which has the advantages of both rapid and high sensitive ion determination (RFA).On the other hand, an active waveguide sensor was designed as a novel highly sensitive ion detection probe. All planar waveguide sensors reported to date employed a waveguide as the only light propagating layr, however, the developed active waveguide optode, utilized the waveguide core, not only as the light propagation layr but also as the molecular recognition layr and transduction layr by inclusion of functional molecules such as neutral ionophores and a lipophilic dye. One of great merits of this waveguide sensor is that a high sensitivity can be obtained even using a miniaturize a probe. The potential applicability of this waveguide was confirmed by constructing two active waveguide ion optodes using a calcium selective ionophore and a sodium selective ionophore. A comparison of the experimental response curves obtained with novel waveguide optode and conventional waveguide optode based on evanescent wave spectrometry clarified that the sensitivity of the novel waveguide optode proposed here is apparently higher than that of the conventional waveguide optode. Less