Studies on Molecular-Cellular Mechanisms of Protein C Anticoagulant Pathway Crucial for Life Homeostasis
Studies on Molecular-Cellular Mechanisms of Protein C Anticoagulant Pathway Crucial for Life Homeostasis
批准号:
21390292
负责人:
SUZUKI Koji
金额:
$11.4万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
We studied the molecular-cellular mechanism of anticoagulant protein C pathway which is crucial for life homeostasis. The results obtained in the research are as follows. (1) Lipopolysaccharide-Toll-like receptor-mediated signaling regulates expression of protein S and C4b-binding protein in the liver. (2) The multi-functional serine protease inhibitor, protein C inhibitor regulates many organ functions beyond thrombosis and hemostasis. (3) Cellular gap junction molecule, connexin32 protects against vascular inflammation by modulating inflammatory cytokine expression by endothelial cells.
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トロンボモジュリンを介した凝固炎症反応と敗血症性DIC
血栓调节蛋白介导的凝血炎症反应和脓毒症 DIC
DOI:
--
发表时间:
2011
期刊:
Thrombosis Medicine
影响因子:
--
作者:
[岡本貴行, 鈴木宏治]
通讯作者:
鈴木宏治
Phosphoinositide 3-kinase induced activation and cytoskeletal translocation of protein kinase CK2 in protease activated receptor 1-stimulated platelets.
磷酸肌醇 3-激酶诱导蛋白酶激活受体 1 刺激的血小板中蛋白激酶 CK2 的激活和细胞骨架易位。
DOI:
--
发表时间:
2010
期刊:
Thromb.Res.
影响因子:
--
作者:
[Nakanishi K, Suauki K, et al.]
通讯作者:
et al.
スタンダード検査血液学第2版(日本検査血液学会編)
标准实验室血液学第2版(日本实验室血液学会编)
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[鈴木宏治, 他(共著)]
通讯作者:
他(共著)
スタンダード検査血液学(第2版)
标准实验室血液学(第二版)
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[伊藤克敏, 館由紀子, 井上敏, 荒川秀俊, 吉田 美香, 伊藤克敏, 内藤 澄悦, 家子 正裕, 伊藤克敏, 岩崎 純子, 伊藤克敏, 伊藤克敏, 家子正裕, 伊藤克敏[分担], 家子 正裕]
通讯作者:
家子 正裕
予防ハンドブック-エキスパートオピニオン-
预防手册-专家意见-
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[鈴木宏治, 他]
通讯作者:
他
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